Platelet-Activating Factor Receptor (PTAFR) ELISA Kit for Human

This gene encodes a seven-transmembrane G-protein-coupled receptor for platelet-activating factor (PAF) that localizes to lipid rafts and/or caveolae in the cell membrane. PAF (1-0-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine) is a phospholipid that plays a significant role in oncogenic transformation, tumor growth, angiogenesis, metastasis, and pro-inflammatory processes. Binding of PAF to the PAF-receptor (PAFR) stimulates numerous signal transduction pathways including phospholipase C, D, A2, mitogen-activated protein kinases (MAPKs), and the phosphatidylinositol-calcium second messenger system. Following PAFR activation, cells become rapidly desensitized and this refractory state is dependent on PAFR phosphorylation, internalization, and down-regulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

PTAFR: Receptor for platelet activating factor, a chemotactic phospholipid mediator that possesses potent inflammatory, smooth- muscle contractile and hypotensive activity. Seems to mediate its action via a G protein that activates a phosphatidylinositol- calcium second messenger system. Belongs to the G-protein coupled receptor 1 family.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Motility/polarity/chemotaxis; Receptor, GPCR

Chromosomal Location of Human Ortholog: 1p35.3

Cellular Component: integral component of membrane; integral component of plasma membrane; membrane; plasma membrane; secretory granule membrane

Molecular Function: G-protein coupled purinergic nucleotide receptor activity; G-protein coupled receptor activity; lipopolysaccharide binding; lipopolysaccharide receptor activity; mitogen-activated protein kinase binding; phospholipid binding; platelet activating factor receptor activity

Biological Process: chemotaxis; cytokine production; G-protein coupled receptor signaling pathway; immune response; inflammatory response; inositol trisphosphate biosynthetic process; lipopolysaccharide-mediated signaling pathway; negative regulation of blood pressure; neutrophil degranulation; parturition; phosphoinositide-mediated signaling; positive regulation of interleukin-6 biosynthetic process; positive regulation of neutrophil degranulation; positive regulation of smooth muscle cell proliferation; positive regulation of translation; positive regulation of tumor necrosis factor production; positive regulation of vasoconstriction; regulation of transcription from RNA polymerase II promoter; response to symbiotic bacterium; transcytosis