Poly (Rc)-Binding Protein 1 (PCBP1) ELISA Kit for Human

This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP-2 and hnRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5'-terminal cloverleaf structure. It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability. [provided by RefSeq, Jul 2008]

hnRNP E1: Single-stranded nucleic acid binding protein that binds preferentially to oligo dC. Abundantly expressed in skeletal muscle, thymus and peripheral blood leukocytes while a lower expression is observed in prostate, spleen, testis, ovary, small intestine, heart, liver, adrenal and thyroid glands.

Protein type: RNA splicing; RNA-binding; Translation

Chromosomal Location of Human Ortholog: 2p13.3

Cellular Component: cytoplasm; cytoplasmic ribonucleoprotein granule; cytosol; extracellular exosome; membrane; nuclear speck; nucleoplasm

Molecular Function: cadherin binding; mRNA binding; protein binding; RNA binding; sequence-specific single stranded DNA binding; single-stranded DNA binding

Biological Process: mRNA splicing, via spliceosome; positive regulation of transcription from RNA polymerase II promoter; RNA metabolic process