Vascular Endothelial Cell Growth Factor Receptor 2 (VEGFR-2/FLK-1) ELISA Kit for Rat

VEGFR2: a receptor tyrosine kinase of the VEGFR family. High affinity receptor for VEGF and VEGF-C. Ligand binding induces autophosphorylation and activation. Activated receptor recruits proteins including Shc, GRB2, PI3K, Nck, SHP-1 and SHP-2. Plays a key role in vascular development and regulation of vascular permeability.

Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group; VEGFR family

Chromosomal Location of Human Ortholog: 14p11

Cellular Component: cell junction; cell periphery; cell soma; cell surface; cytoplasm; early endosome; endoplasmic reticulum; endosome; external side of plasma membrane; Golgi apparatus; integral component of membrane; integral component of plasma membrane; membrane raft; neuron projection; nucleus; plasma membrane

Molecular Function: ATP binding; growth factor binding; identical protein binding; integrin binding; protein binding; protein tyrosine kinase activity; vascular endothelial growth factor binding; vascular endothelial growth factor-activated receptor activity

Biological Process: aging; alveolus development; angiogenesis; branching morphogenesis of a tube; calcium ion homeostasis; cell fate commitment; cell maturation; cell migration; cell migration during sprouting angiogenesis; elevation of cytosolic calcium ion concentration; embryonic hemopoiesis; endocardium development; endochondral bone growth; endothelial cell differentiation; endothelium development; ERK1 and ERK2 cascade; hemopoiesis; hyaluronan metabolic process; lung development; lymph vessel development; male gonad development; negative regulation of apoptosis; negative regulation of endothelial cell apoptotic process; negative regulation of neuron apoptosis; neuron projection morphogenesis; ovarian follicle development; peptidyl-tyrosine autophosphorylation; peptidyl-tyrosine phosphorylation; positive regulation of angiogenesis; positive regulation of blood vessel diameter; positive regulation of BMP signaling pathway; positive regulation of calcium-mediated signaling; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway; positive regulation of endothelial cell migration; positive regulation of endothelial cell proliferation; positive regulation of epithelial cell proliferation; positive regulation of ERK1 and ERK2 cascade; positive regulation of focal adhesion assembly; positive regulation of long-term neuronal synaptic plasticity; positive regulation of macroautophagy; positive regulation of MAPK cascade; positive regulation of mesenchymal cell proliferation; positive regulation of mitochondrial depolarization; positive regulation of mitochondrial fission; positive regulation of neurogenesis; positive regulation of nitric-oxide synthase biosynthetic process; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of positive chemotaxis; positive regulation of protein phosphorylation; positive regulation of TOR signaling pathway; positive regulation of vasculogenesis; post-embryonic camera-type eye morphogenesis; protein autophosphorylation; protein kinase B signaling; regulation of cell shape; regulation of endothelial cell differentiation; regulation of hematopoietic progenitor cell differentiation; response to drug; response to hypoxia; surfactant homeostasis; vascular endothelial growth factor receptor signaling pathway; vascular endothelial growth factor signaling pathway; vasculogenesis