Potassium Voltage-Gated Channel Subfamily C Member 4x (KCNC3) ELISA Kit for Human

Name: Human KCNC3 ELISA Kit; MyBioSource
Brand: MyBioSource
SKU: MBS282646
Price: 495 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS282646

Intended Uses: For the quantitative detection of Human Potassium channel subfamily T member 1 (KCNT1) concentration in serum, plasma and other biological fluids.Principle of the Assay: This assay employs a two-site sandwich ELISA to quantitate KCNT1 in Human… More details

$495 / 48 Tests +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

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Product Overview

Online Datasheet in PDF

Product Name

Potassium voltage-gated channel subfamily C member 4x (KCNC3), ELISA Kit

Full Product Name

Human Potassium voltage-gated channel subfamily C member 4 (KCNC4) ELISA Kit

Product Gene Name

KCNC3 elisa kit

Species Reactivity

Human

Assay Type

Quantitative Sandwich

Samples

Serum, Plasma And Other Biological Fluids

Detection Range

125 pg/mL-8000 pg/mL

Sensitivity

83.3 pg/mL (mean of 6 independent assays).

Specificity

This assay has high sensitivity and excellent specificity for detection of Human KCNT1. No significant cross-reactivity or interference between Human KCNT1 and analogues was observed.

Preparation and Storage

Store at 2-8 degree C.

Inter-assay Precision

Inter-assay Precision (Precision between assays) Three samples of known concentration were tested in forty separate assays to assess inter-assay precision. CV (%) = SD/meanX100. Inter-Assay: CV<12%

Intra-assay Precision

Intra-assay Precision (Precision within an assay) Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision. Intra-Assay: CV<8%

Molecular Weight

68,824 Da

OMIM

M64676 mRNA

3D Structure

ModBase 3D Structure for Q03721

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of KCNC3 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KCNC3 purchase

MBS282646 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Potassium voltage-gated channel subfamily C member 4x (KCNC3) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing KCNC3. The ELISA analytical biochemical technique of the MBS282646 kit is based on KCNC3 antibody-KCNC3 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect KCNC3 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, KCNC3. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for KCNC3. It may not necessarily be applicable to this product.

NCBI GI #

88758576

NCBI GeneID

3749

NCBI Accession #

NP_001034663.1

UniProt Primary Accession #

Q03721

UniProt Secondary Accession #

Q3MIM4; Q5TBI6

UniProt Related Accession #

Q03721

GenBank Nucleotide #

NM_001039574.2

NCBI Official Full Name

potassium voltage-gated channel subfamily C member 4 isoform c

NCBI Official Synonym Full Names

potassium voltage-gated channel subfamily C member 4

NCBI Official Symbol

KCNC4

NCBI Official Synonym Symbols

KV3.4; C1orf30; KSHIIIC; HKSHIIIC

UniProt Protein Name

Potassium voltage-gated channel subfamily C member 4

UniProt Synonym Protein Names

KSHIIIC; Voltage-gated potassium channel subunit Kv3.4

Protein Family

Potassium voltage-gated channel subfamily

UniProt Gene Name

KCNC4

NCBI Protein Information

potassium voltage-gated channel subfamily C member 4

NCBI Summary for KCNC3

The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. It generates atypical voltage-dependent transient current that may be important for neuronal excitability. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jul 2010]

UniProt Comments for KCNC3

Kv3.4: This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.4/KCNC4 sub-subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1p13.3

Cellular Component: axon terminus; integral component of membrane; neuromuscular junction; plasma membrane; voltage-gated potassium channel complex

Molecular Function: potassium channel activity; voltage-gated potassium channel activity

Biological Process: potassium ion transmembrane transport; potassium ion transport; protein homooligomerization; regulation of ion transmembrane transport; regulation of neurotransmitter secretion; synaptic transmission

Research Articles on KCNC3

1. This study provides original evidence to demonstrate the early occurrence and high prevalence of abnormal Kv3.4 expression in oral leucoplakias. Our results support a role for Kv3.4 potassium channel in OSCC tumorigenesis rather than tumour progression and disease outcome.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with KCNC3 elisa kit

Products by Pathway	Pathway Diagram
Neuronal System Pathway antibodies	Neuronal System Pathway Diagram
Potassium Channels Pathway antibodies	Potassium Channels Pathway Diagram
Voltage Gated Potassium Channels Pathway antibodies	Voltage Gated Potassium Channels Pathway Diagram

Diseases associated with KCNC3 elisa kit

Disease Name	Pubmed Publications
Disease Models, Animal Antibodies	>4 publications with KCNC3 and Disease Models, Animal
Epilepsy Antibodies	>2 publications with KCNC3 and Epilepsy
Carcinoma Antibodies	>2 publications with KCNC3 and Carcinoma
Arrhythmias, Cardiac Antibodies	>1 publications with KCNC3 and Arrhythmias, Cardiac
Seizures Antibodies	>1 publications with KCNC3 and Seizures
Hypertrophy Antibodies	>1 publications with KCNC3 and Hypertrophy
Acidosis Antibodies	>1 publications with KCNC3 and Acidosis
Epilepsy, Temporal Lobe Antibodies	>1 publications with KCNC3 and Epilepsy, Temporal Lobe

Organs/Tissues associated with KCNC3 elisa kit

Organ/Tissue Name	Pubmed Publications
Muscle Antibodies	>11 publications with KCNC3 and Muscle
Brain Antibodies	>8 publications with KCNC3 and Brain
Blood Antibodies	>4 publications with KCNC3 and Blood
Heart Antibodies	>3 publications with KCNC3 and Heart
Uterus Antibodies	>2 publications with KCNC3 and Uterus
Stomach Antibodies	>1 publications with KCNC3 and Stomach
Thymus Antibodies	>1 publications with KCNC3 and Thymus
Ovary Antibodies	>1 publications with KCNC3 and Ovary
Eye Antibodies	>1 publications with KCNC3 and Eye
Mouth Antibodies	>1 publications with KCNC3 and Mouth