Wolframin (WFS1) ELISA Kit for Mouse

WFS1: Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store. Highly expressed in heart followed by brain, placenta, lung and pancreas. Weakly expressed in liver, kidney and skeletal muscle. Also expressed in islet and beta-cell insulinoma cell line.

Protein type: Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 5|5 B3

Cellular Component: endoplasmic reticulum; integral component of endoplasmic reticulum membrane; integral component of membrane; membrane; proteasome complex

Molecular Function: activating transcription factor binding; ATPase binding; calcium-dependent protein binding; calmodulin binding; ubiquitin protein ligase binding

Biological Process: calcium ion homeostasis; endoplasmic reticulum calcium ion homeostasis; endoplasmic reticulum unfolded protein response; ER-associated protein catabolic process; glucose homeostasis; kidney development; negative regulation of ATF6-mediated unfolded protein response; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; negative regulation of neuron apoptosis; negative regulation of programmed cell death; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of type B pancreatic cell apoptotic process; neurological system process; positive regulation of adenylate cyclase activity; positive regulation of calcium ion transport; positive regulation of growth; positive regulation of protein metabolic process; positive regulation of protein ubiquitination; protein stabilization; regulation of cell cycle; renal water homeostasis; sensory perception of sound; visual perception