Potassium Voltage-Gated Channel Subfamily D Member 3 (KCND3) ELISA Kit for Human

Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shal-related subfamily, members of which form voltage-activated A-type potassium ion channels and are prominent in the repolarization phase of the action potential. This member includes two isoforms with different sizes, which are encoded by alternatively spliced transcript variants of this gene. [provided by RefSeq, Jul 2008]

Kv4.3: Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits. KCND3 rare variants may confer risk for lethal ventricular arrhytmias and be associated with autopsy-negative sudden unexplained death syndrome (SUDS). Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.3/KCND3 sub-subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Channel, potassium; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 1p13.2

Cellular Component: dendrite; plasma membrane; sarcolemma; voltage-gated potassium channel complex

Molecular Function: A-type (transient outward) potassium channel activity; ion channel binding; metal ion binding; protein binding; voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization; voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization

Biological Process: membrane repolarization; membrane repolarization during cardiac muscle cell action potential; membrane repolarization during ventricular cardiac muscle cell action potential; potassium ion export; potassium ion transport; protein homooligomerization; regulation of heart rate by cardiac conduction; regulation of ion transmembrane transport

Disease: Brugada Syndrome 9; Spinocerebellar Ataxia 19