Zinc Finger Protein 36, C3H1 Type-Like 1 (ZFP36L1) ELISA Kit for Mouse

BRF1: a zinc finger protein that plays an important role in the assembly of the RNA polymerase III initiation factor TFIIIB. Regulates mRNA levels by targeting transcripts containing AREs (AU-rich elements) into the decay pathway. Phosphorylation by Akt apparently generates 14-3-3 binding sites and inhibits BRF1 from promoting mRNA activity.Contains 2 C3H1-type zinc fingers.

Protein type: Transcription factor

Chromosomal Location of Human Ortholog: 12|12 C3

Cellular Component: cytoplasm; cytosol; intracellular ribonucleoprotein complex; nucleus; P-body

Molecular Function: 14-3-3 protein binding; AU-rich element binding; DNA binding; metal ion binding; mRNA binding; protein binding; RNA binding

Biological Process: apoptosis; cell proliferation; cellular response to cAMP; cellular response to epidermal growth factor stimulus; cellular response to fibroblast growth factor stimulus; cellular response to glucocorticoid stimulus; cellular response to hypoxia; cellular response to insulin stimulus; cellular response to peptide hormone stimulus; cellular response to phorbol 13-acetate 12-myristate; cellular response to salt stress; cellular response to transforming growth factor beta stimulus; cellular response to tumor necrosis factor; embryonic organ development; ERK1 and ERK2 cascade; heart development; MAPK cascade; mesendoderm development; mRNA catabolic process; mRNA catabolic process, deadenylation-dependent decay; mRNA catabolic process, deadenylation-independent decay; mRNA processing; mRNA transport; multicellular organism development; multicellular organism growth; negative regulation of erythrocyte differentiation; negative regulation of mitotic cell cycle phase transition; neural tube development; p38MAPK cascade; phosphoinositide 3-kinase cascade; positive regulation of fat cell differentiation; positive regulation of intracellular mRNA localization; positive regulation of monocyte differentiation; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; proepicardium development; protein kinase B signaling; regulation of B cell differentiation; regulation of gene expression; regulation of keratinocyte apoptotic process; regulation of keratinocyte differentiation; regulation of keratinocyte proliferation; regulation of mRNA 3'-end processing; regulation of mRNA stability; regulation of myoblast differentiation; regulation of stem cell proliferation; regulation of translation; response to wounding; T cell differentiation in thymus; transport; vasculogenesis