Podoplanin (PDPN) ELISA Kit for Human

This gene encodes a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined but it has been proposed as a marker of lung injury. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

PDPN: May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels. Belongs to the podoplanin family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 1p36.21

Cellular Component: apical plasma membrane; basolateral plasma membrane; cell projection; cytoplasmic vesicle; cytosol; external side of plasma membrane; filopodium; filopodium membrane; integral component of plasma membrane; lamellipodium; membrane; membrane raft; microvillus membrane; plasma membrane; ruffle

Molecular Function: amino acid transmembrane transporter activity; chaperone binding; chemokine binding; folic acid transporter activity; protein binding; receptor binding; water channel activity; water transmembrane transporter activity

Biological Process: alveolus development; amino acid transport; cell morphogenesis; cell proliferation; folic acid transport; lung development; lymph node development; lymphangiogenesis; negative regulation of apoptosis; negative regulation of cell proliferation; platelet activation; positive regulation of cell migration; positive regulation of cellular component movement; prostaglandin metabolic process; regulation of cell shape; Rho protein signal transduction; water transport