5-Hydroxytryptamine Receptor 2c (HTR2C) ELISA Kit for Rat

Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in rodents show altered patterns of RNA editing in response to drug treatments and stressful situations. [provided by RefSeq, Jul 2008]

5-HT(2C): a G-protein coupled receptor. One of several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Mediates its action by activating a phosphatidylinositol-calcium second messenger system.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: Xq34

Cellular Component: cell surface; external side of plasma membrane; integral component of plasma membrane; intracellular; plasma membrane

Molecular Function: 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding; drug binding; G-protein coupled serotonin receptor activity; Gq/11-coupled serotonin receptor activity; neurotransmitter receptor activity; protein binding; serotonin binding

Biological Process: behavioral fear response; behavioral response to nicotine; cellular calcium ion homeostasis; cGMP biosynthetic process; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); feeding behavior; G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger; G-protein coupled serotonin receptor signaling pathway; G-protein signaling, phospholipase D activating pathway; inositol phosphate-mediated signaling; locomotory behavior; negative regulation of dopamine metabolic process; negative regulation of locomotion; organ regeneration; phospholipase C-activating G-protein coupled receptor signaling pathway; phospholipase C-activating serotonin receptor signaling pathway; positive regulation of acetylcholine secretion, neurotransmission; positive regulation of ERK1 and ERK2 cascade; positive regulation of fat cell differentiation; positive regulation of gamma-aminobutyric acid secretion; positive regulation of phosphatidylinositol biosynthetic process; positive regulation of vasoconstriction; regulation of appetite; regulation of corticotropin-releasing hormone secretion; regulation of neurological process; regulation of sensory perception of pain; release of sequestered calcium ion into cytosol; response to drug; serotonin receptor signaling pathway