Growth Hormone Releasing (GHRP) ELISA Kit for Rabbit

This gene encodes a member of the G-protein coupled receptor family. The encoded protein may play a role in energy homeostasis and regulation of body weight. Two identified transcript variants are expressed in several tissues and are evolutionary conserved in fish and swine. One transcript, 1a, excises an intron and encodes the functional protein; this protein is the receptor for the Ghrelin ligand and defines a neuroendocrine pathway for growth hormone release. The second transcript (1b) retains the intron and does not function as a receptor for Ghrelin; however, it may function to attenuate activity of isoform 1a. Mutations in this gene are associated with autosomal idiopathic short stature.[provided by RefSeq, Apr 2010]

GHSR: Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine). Defects in GHSR may be a cause of idiopathic short stature autosomal (ISSA). Short stature is defined by a subnormal rate of growth. Belongs to the G-protein coupled receptor 1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral; GPCR, family 1

Chromosomal Location of Human Ortholog: 3q26.31

Cellular Component: cell surface; integral to membrane; lipid raft; neuron projection; plasma membrane

Molecular Function: G-protein coupled receptor activity; growth hormone secretagogue receptor activity; growth hormone-releasing hormone receptor activity; peptide hormone binding

Biological Process: actin polymerization and/or depolymerization; adult feeding behavior; cellular response to insulin stimulus; decidualization; G-protein coupled receptor protein signaling pathway; growth hormone secretion; hormone-mediated signaling; negative regulation of inflammatory response; negative regulation of insulin secretion; negative regulation of interleukin-1 beta production; negative regulation of interleukin-6 biosynthetic process; negative regulation of tumor necrosis factor biosynthetic process; positive regulation of appetite; positive regulation of fatty acid metabolic process; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of multicellular organism growth; regulation of hindgut contraction; regulation of synaptogenesis; response to food; response to hormone stimulus

Disease: Short Stature, Idiopathic, Autosomal