High Mobility Group Protein B1 (HMGB-1) ELISA Kit for Human

This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2015]

HMGB1: DNA binding proteins that associates with chromatin and has the ability to bend DNA. Binds preferentially single-stranded DNA. Involved in V(D)J recombination by acting as a cofactor of the RAG complex. Acts by stimulating cleavage and RAG protein binding at the 23 bp spacer of conserved recombination signal sequences (RSS). Heparin-binding protein that has a role in the extension of neurite-type cytoplasmic processes in developing cells. Component of the RAG complex composed of core components RAG1 and RAG2, and associated component HMGB1 or HMGB2. Belongs to the HMGB family.

Protein type: DNA repair, damage; Nuclear receptor co-regulator

Chromosomal Location of Human Ortholog: 13q12.3

Cellular Component: cell surface; condensed chromosome; endoplasmic reticulum-Golgi intermediate compartment; endosome; extracellular region; extracellular space; ficolin-1-rich granule lumen; nucleoplasm; nucleus; plasma membrane; secretory granule lumen; transcriptional repressor complex

Molecular Function: bubble DNA binding; C-X-C chemokine binding; chemoattractant activity; cytokine activity; damaged DNA binding; DNA binding transcription factor activity; DNA binding, bending; double-stranded DNA binding; four-way junction DNA binding; lipopolysaccharide binding; lyase activity; phosphatidylserine binding; protein binding; RAGE receptor binding; RNA binding; single-stranded DNA binding; transcription factor binding

Biological Process: activation of innate immune response; apoptotic cell clearance; apoptotic DNA fragmentation; autophagy; dendritic cell chemotaxis; DNA geometric change; DNA ligation involved in DNA repair; DNA recombination; DNA topological change; elevation of cytosolic calcium ion concentration; inflammatory response; inflammatory response to antigenic stimulus; innate immune response; myeloid dendritic cell activation; negative regulation of blood vessel endothelial cell migration; negative regulation of CD4-positive, alpha beta T cell differentiation; negative regulation of interferon-gamma production; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcriptional preinitiation complex assembly; neuron projection development; neutrophil degranulation; positive chemotaxis; positive regulation of activated T cell proliferation; positive regulation of apoptosis; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of dendritic cell differentiation; positive regulation of DNA binding; positive regulation of DNA ligation; positive regulation of ERK1 and ERK2 cascade; positive regulation of interleukin-1 secretion; positive regulation of interleukin-10 production; positive regulation of interleukin-12 production; positive regulation of interleukin-6 secretion; positive regulation of JNK cascade; positive regulation of MAPK cascade; positive regulation of mismatch repair; positive regulation of monocyte chemotaxis; positive regulation of toll-like receptor 9 signaling pathway; positive regulation of transcription from RNA polymerase II promoter; regulation of autophagy; regulation of receptor activity; regulation of restriction endodeoxyribonuclease activity; regulation of T cell mediated immune response to tumor cell; regulation of tolerance induction; regulation of transcription from RNA polymerase II promoter; T-helper 1 cell differentiation; toll-like receptor signaling pathway; V(D)J recombination