C-Myc Oncogene Product (c-MYC) ELISA Kit for Human

This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017]

Myc: a proto-oncogenic transcription factor that plays a role in cell proliferation, apoptosis and in the development of human tumors. Seems to activate the transcription of growth-related genes.

Protein type: DNA-binding; Nucleolus; Oncoprotein; Transcription factor

Chromosomal Location of Human Ortholog: 8q24.21

Cellular Component: cytosol; nuclear chromatin; nucleolus; nucleoplasm; nucleus; protein complex

Molecular Function: activating transcription factor binding; DNA binding; DNA binding transcription factor activity; protein binding; protein complex binding; protein dimerization activity; transcription factor binding

Biological Process: beta-catenin-TCF complex assembly; branching involved in ureteric bud morphogenesis; cell cycle arrest; cellular iron ion homeostasis; cellular response to DNA damage stimulus; cellular response to hypoxia; cellular response to UV; chromatin remodeling; chromosome organization and biogenesis; energy reserve metabolic process; ERK1 and ERK2 cascade; fibroblast apoptotic process; G1/S transition of mitotic cell cycle; MAPK cascade; negative regulation of apoptosis; negative regulation of cell division; negative regulation of fibroblast proliferation; negative regulation of monocyte differentiation; negative regulation of stress-activated MAPK cascade; negative regulation of transcription from RNA polymerase II promoter; Notch signaling pathway; oxygen transport; positive regulation of cell proliferation; positive regulation of cysteine-type endopeptidase activity involved in apoptotic process; positive regulation of DNA biosynthetic process; positive regulation of epithelial cell proliferation; positive regulation of fibroblast proliferation; positive regulation of gene expression; positive regulation of mesenchymal cell proliferation; positive regulation of metanephric cap mesenchymal cell proliferation; positive regulation of response to DNA damage stimulus; positive regulation of telomerase activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-templated; protein deubiquitination; protein-DNA complex disassembly; regulation of gene expression; regulation of telomere maintenance; regulation of transcription from RNA polymerase II promoter; response to drug; response to gamma radiation; transcription from RNA polymerase II promoter; Wnt receptor signaling pathway through beta-catenin

Disease: Burkitt Lymphoma