Interleukin-6 (IL6ST) ELISA Kit for Human

The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggest that this gene plays a critical role in regulating myocyte apoptosis. Alternatively spliced transcript variants have been described. A related pseudogene has been identified on chromosome 17. [provided by RefSeq, May 2014]

gp130: gp130 is a ubiquitously expressed type I cytokine family receptor. The receptor systems for IL6, LIF, OSM, CNTF, IL11 AND CT1 utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not directly bind IL6. May have a role in embryonic development. Contains 5 fibronectin type III domains and 1 immunoglobulin-like C2-type domain. Two alternatively spliced isoforms have been described.

Protein type: Membrane protein, integral; Receptor, cytokine

Chromosomal Location of Human Ortholog: 5q11.2

Cellular Component: cell soma; ciliary neurotrophic factor receptor complex; dendrite; external side of plasma membrane; extracellular exosome; extracellular region; interleukin-6 receptor complex; membrane; oncostatin-M receptor complex; plasma membrane

Molecular Function: ciliary neurotrophic factor receptor activity; ciliary neurotrophic factor receptor binding; growth factor binding; interleukin-11 binding; interleukin-11 receptor activity; interleukin-27 receptor activity; interleukin-6 binding; interleukin-6 receptor activity; interleukin-6 receptor binding; leukemia inhibitory factor receptor activity; oncostatin-M receptor activity; protein binding; protein homodimerization activity

Biological Process: ciliary neurotrophic factor-mediated signaling pathway; cytokine-mediated signaling pathway; glycogen metabolic process; interleukin-11-mediated signaling pathway; interleukin-27-mediated signaling pathway; interleukin-6-mediated signaling pathway; leukemia inhibitory factor signaling pathway; negative regulation of apoptosis; oncostatin-M-mediated signaling pathway; positive regulation of acute inflammatory response; positive regulation of adaptive immune response; positive regulation of astrocyte differentiation; positive regulation of cardiac muscle hypertrophy; positive regulation of cell proliferation; positive regulation of osteoblast differentiation; positive regulation of T cell proliferation; positive regulation of tyrosine phosphorylation of STAT protein; positive regulation of vascular endothelial growth factor production; regulation of Notch signaling pathway; response to cytokine; viral process