Arginase-1 (ARG1) ELISA Kit for Human

Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

ARG1: Homotrimer. By arginine or homoarginine. Belongs to the arginase family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Amino Acid Metabolism - arginine and proline; EC 3.5.3.1; Hydrolase

Chromosomal Location of Human Ortholog: 6q23.2

Cellular Component: cell soma; cytoplasm; cytosol; extracellular region; extracellular space; mitochondrial outer membrane; neuron projection; nucleus

Molecular Function: arginase activity; manganese ion binding

Biological Process: aging; arginine catabolic process; arginine catabolic process to ornithine; collagen biosynthetic process; defense response to protozoan; liver development; lung development; mammary gland involution; maternal process involved in female pregnancy; negative regulation of activated T cell proliferation; negative regulation of T cell proliferation; neutrophil degranulation; positive regulation of endothelial cell proliferation; response to amine; response to amino acid; response to axon injury; response to cadmium ion; response to drug; response to herbicide; response to manganese ion; response to methylmercury; response to selenium ion; response to vitamin A; response to vitamin E; response to zinc ion; urea cycle

Disease: Argininemia