Son of Sevenless Homolog 1 (SOS1) ELISA Kit for Mouse

Name: Mouse SOS1 ELISA Kit; Son of Sevenless Homolog 1; MyBioSource
Brand: MyBioSource
SKU: MBS284126
Price: 495 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS284126

Principle of the Assay: This assay employs a two-site sandwich ELISA to quantitate SOS1 in samples. An antibody specific for SOS1 has been pre-coated onto a microplate. Standards and samples are pipetted into the wells and anySOS1 present is bound by the… More details

$495 / 48 Tests +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

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Product Overview

Online Datasheet in PDF

Product Name

Son of sevenless homolog 1 (SOS1), ELISA Kit

Full Product Name

Mouse Son of sevenless homolog 1 (SOS1) ELISA Kit

Product Gene Name

SOS1 elisa kit

Product Synonym Names

GF1; GGF1; GINGF; HGF; NS4; OTTHUMP00000128306|gingival fibromatosis; hereditary; 1|guanine nucleotide exchange factor|son of sevenless homolog 1

Species Reactivity

Mouse

Assay Type

Sandwich

Samples

Serum, Plasma, Other biological fluids

Specificity

This assay has high sensitivity and excellent specificity for detection of Mouse SOS1. No significant cross-reactivity or interference between Mouse SOS1 and analogues was observed.

Preparation and Storage

Store at 2-8 degree C.

Molecular Weight

150,883 Da

3D Structure

ModBase 3D Structure for Q62245

Sample Volume

1-200 uL

Precision

Intra-assay Precision (Precision within an assay)
Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.
Inter-assay Precision (Precision between assays)
Three samples of known concentration were tested in forty separate assays to assess inter-assay precision.
CV (%) = SD/meanX100
Intra-Assay: CV
Inter-Assay: CV

Detection Wavelength

450 nm

ISO Certification

Manufactured in an ISO 9001:2015 Certified Laboratory.

Other Notes

Small volumes of SOS1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for SOS1 purchase

MBS284126 is a ready-to-use microwell, strip-or-full plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Son of sevenless homolog 1 (SOS1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing SOS1. The ELISA analytical biochemical technique of the MBS284126 kit is based on SOS1 antibody-SOS1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect SOS1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, SOS1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for SOS1. It may not necessarily be applicable to this product.

NCBI GI #

117414170

NCBI GeneID

20662

NCBI Accession #

NP_033257.2

UniProt Primary Accession #

Q62245

UniProt Secondary Accession #

Q62244

UniProt Related Accession #

Q62245

GenBank Nucleotide #

NM_009231.2

NCBI Official Full Name

son of sevenless homolog 1

NCBI Official Synonym Full Names

SOS Ras/Rac guanine nucleotide exchange factor 1

NCBI Official Symbol

Sos1

NCBI Official Synonym Symbols

AI449023; 9630010N06; 4430401P03Rik

UniProt Protein Name

Son of sevenless homolog 1

Protein Family

Son of sevenless

UniProt Gene Name

Sos1

UniProt Synonym Gene Names

SOS-1; mSOS-1

NCBI Protein Information

son of sevenless homolog 1

UniProt Comments for SOS1

SOS1: a guanine nucleotide exchange factor that activates Ras by catalyzing the exchange of bound GDP for GTP. Interacts with GRB2, NCK, and other adapter proteins. Plays an important role in signaling pathways leading from the G-protein- coupled receptors and receptor tyrosine kinases to MAPK/ERK.

Protein type: Adaptor/scaffold; GEF; GEF, Ras; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17 E3|17 50.67 cM

Cellular Component: cell soma; cytoplasm; plasma membrane; postsynaptic density

Molecular Function: DNA binding; guanyl-nucleotide exchange factor activity; protein binding; protein heterodimerization activity; Ras guanyl-nucleotide exchange factor activity; Rho guanyl-nucleotide exchange factor activity; SH3 domain binding

Biological Process: B cell homeostasis; blood vessel morphogenesis; cardiac atrium morphogenesis; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; hair follicle development; heart morphogenesis; lymphocyte homeostasis; midbrain morphogenesis; multicellular organism growth; nerve growth factor receptor signaling pathway; palate development; pericardium morphogenesis; positive regulation of Ras protein signal transduction; positive regulation of small GTPase mediated signal transduction; Ras protein signal transduction; regulation of pro-B cell differentiation; regulation of Rho protein signal transduction; regulation of T cell differentiation in the thymus; regulation of T cell proliferation; small GTPase mediated signal transduction; vitellogenesis

Research Articles on SOS1

1. a direct mechanistic link between Sos1 and control of intracellular oxidative stress, and demonstrate functional prevalence of Sos1 over Sos2 with regards to cellular proliferation and viability.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with SOS1 elisa kit

Reference Product	PubMed Publications
Grb2 elisa kit	>116 publications with SOS1 and Grb2
Src elisa kit	>56 publications with SOS1 and Src
Mapk3 elisa kit	>12 publications with SOS1 and Mapk3
Mapk1 elisa kit	>11 publications with SOS1 and Mapk1
Crk elisa kit	>4 publications with SOS1 and Crk
Csf1r elisa kit	>3 publications with SOS1 and Csf1r
Ptpn6 elisa kit	>2 publications with SOS1 and Ptpn6
Pik3r1 elisa kit	>2 publications with SOS1 and Pik3r1
Fyn elisa kit	>2 publications with SOS1 and Fyn

Pathways associated with SOS1 elisa kit

Products by Pathway	Pathway Diagram
Activation Of Rac Pathway antibodies	Activation Of Rac Pathway Diagram
Acute Myeloid Leukemia Pathway antibodies	Acute Myeloid Leukemia Pathway Diagram
Acute Myeloid Leukemia Pathway antibodies	Acute Myeloid Leukemia Pathway Diagram
Alcoholism Pathway antibodies	Alcoholism Pathway Diagram
Alcoholism Pathway antibodies	Alcoholism Pathway Diagram
Axon Guidance Pathway antibodies	Axon Guidance Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
B Cell Receptor Signaling Pathway antibodies	B Cell Receptor Signaling Pathway Diagram
Cell Death Signalling Via NRAGE, NRIF And NADE Pathway antibodies	Cell Death Signalling Via NRAGE, NRIF And NADE Pathway Diagram

Diseases associated with SOS1 elisa kit

Disease Name	Pubmed Publications
Congenital Abnormalities Antibodies	>74 publications with SOS1 and Congenital Abnormalities
Noonan Syndrome Antibodies	>71 publications with SOS1 and Noonan Syndrome
Heart Defects, Congenital Antibodies	>63 publications with SOS1 and Heart Defects, Congenital
Heart Diseases Antibodies	>62 publications with SOS1 and Heart Diseases
Neoplasms Antibodies	>59 publications with SOS1 and Neoplasms
Skin Diseases Antibodies	>19 publications with SOS1 and Skin Diseases
Noonan Syndrome 4 Antibodies	>12 publications with SOS1 and Noonan Syndrome 4
Cell Transformation, Neoplastic Antibodies	>11 publications with SOS1 and Cell Transformation, Neoplastic
Nervous System Diseases Antibodies	>9 publications with SOS1 and Nervous System Diseases
Carcinoma Antibodies	>9 publications with SOS1 and Carcinoma

Organs/Tissues associated with SOS1 elisa kit

Organ/Tissue Name	Pubmed Publications
Embryonic Tissue Antibodies	>6 publications with SOS1 and Embryonic Tissue
Mixed Antibodies	>2 publications with SOS1 and Mixed
Bone Marrow Antibodies	>2 publications with SOS1 and Bone Marrow