Immunoglobulin (HSPA5) ELISA Kit for Human

The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. It is localized in the lumen of the endoplasmic reticulum (ER), and is involved in the folding and assembly of proteins in the ER. As this protein interacts with many ER proteins, it may play a key role in monitoring protein transport through the cell.[provided by RefSeq, Sep 2010]

GRP78: a member of the HSP family of molecular chaperones required for endoplasmic reticulum integrity and stress-induced autophagy. Plays a central role in regulating the unfolded protein response (UPR), and is an obligatory component of autophagy in mammalian cells. May play an important role in cellular adaptation and oncogenic survival. One of the client proteins of GRP78 is protein double-stranded RNA-activated protein-like endoplasmic reticulum kinase (PERK). Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER.

Protein type: Chaperone; Heat shock protein

Chromosomal Location of Human Ortholog: 9q33.3

Cellular Component: cell surface; endoplasmic reticulum; endoplasmic reticulum chaperone complex; endoplasmic reticulum lumen; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment; extracellular exosome; extracellular matrix; focal adhesion; integral component of endoplasmic reticulum membrane; melanosome; membrane; midbody; mitochondrion; myelin sheath; nucleus; plasma membrane; protein complex; signalosome; smooth endoplasmic reticulum

Molecular Function: ATP binding; ATPase activity; cadherin binding; calcium ion binding; chaperone binding; enzyme binding; misfolded protein binding; protein binding; protein domain specific binding; ribosome binding; ubiquitin protein ligase binding; unfolded protein binding

Biological Process: activation of signaling protein activity involved in unfolded protein response; ATF6-mediated unfolded protein response; cellular response to calcium ion; cellular response to cAMP; cellular response to gamma radiation; cellular response to glucose starvation; cellular response to interleukin-4; cellular response to manganese ion; cerebellar Purkinje cell layer development; cerebellum structural organization; endoplasmic reticulum unfolded protein response; ER overload response; ER-associated protein catabolic process; IRE1-mediated unfolded protein response; negative regulation of apoptosis; negative regulation of protein homodimerization activity; negative regulation of transforming growth factor beta receptor signaling pathway; neuron apoptosis; neuron differentiation; PERK-mediated unfolded protein response; positive regulation of cell migration; positive regulation of neuron projection development; positive regulation of protein ubiquitination; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress; regulation of ATF6-mediated unfolded protein response; regulation of IRE1-mediated unfolded protein response; regulation of PERK-mediated unfolded protein response; response to cocaine; response to methamphetamine hydrochloride; substantia nigra development; toxin transport