Obscurin (OBSCN) ELISA Kit for Human

The obscurin gene spans more than 150 kb, contains over 80 exons and encodes a protein of approximately 720 kDa. The encoded protein contains 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with an associated PH domain, and 2 serine-threonine kinase domains. This protein belongs to the family of giant sacromeric signaling proteins that includes titin and nebulin, and may have a role in the organization of myofibrils during assembly and may mediate interactions between the sarcoplasmic reticulum and myofibrils. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

OBSCN: a Ca(2+)/calmodulin-dependent protein kinase of the Trio family. A giant protein with one Rho GEF domain, one PH domain and two kinase domains. Expressed in skeletal and cardiac muscle, concentrating around Z-disks and M-lines of striated muscle. Binds ankyrin 1 interacts with sarcomeric myosin. May play a critical role in its ability to assemble into A bands in striated muscle.

Protein type: CAMK group; EC 2.7.11.1; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Trio family

Chromosomal Location of Human Ortholog: 1q42.13

Cellular Component: cytosol; M band; myofibril; nuclear body; plasma membrane; sarcolemma; Z disc

Molecular Function: ankyrin binding; ATP binding; calmodulin binding; guanyl-nucleotide exchange factor activity; metal ion binding; protein binding; protein serine/threonine kinase activity; Rho guanyl-nucleotide exchange factor activity; structural constituent of muscle; titin binding

Biological Process: G-protein coupled receptor signaling pathway; multicellular organism development; positive regulation of apoptosis; protein amino acid phosphorylation; regulation of molecular function; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; sarcomere organization