Glycogen Synthase Kinase-3 Beta (GSK3B) ELISA Kit for Rat

GSK3B: a proline-directed protein kinase of the GSK family. Phosphorylates and inactivates glycogen synthase. Participates in the Wnt signaling pathway. Involved in energy metabolism, neuronal cell development, and body pattern formation

Protein type: CMGC group; EC 2.7.11.1; EC 2.7.11.26; GSK family; GSK subfamily; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)

Chromosomal Location of Human Ortholog: 11q21

Cellular Component: axon; beta-catenin destruction complex; cell body; cell soma; centrosome; cytoplasm; cytosol; dendrite; dendritic shaft; dendritic spine; growth cone; intracellular ribonucleoprotein complex; membrane; membrane raft; microtubule; mitochondrion; nucleus; perinuclear region of cytoplasm; plasma membrane; postsynaptic density; protein complex; Wnt signalosome

Molecular Function: ATP binding; beta-catenin binding; integrin binding; ionotropic glutamate receptor binding; kinase activity; NF-kappaB binding; p53 binding; protease binding; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; tau protein binding; tau-protein kinase activity; transcription factor binding; ubiquitin protein ligase binding

Biological Process: aging; axonogenesis; canonical Wnt signaling pathway involved in positive regulation of apoptotic process; cell migration; cellular response to amyloid-beta; cellular response to hydrogen peroxide; cellular response to iron(II) ion; cellular response to lithium ion; circadian rhythm; epithelial to mesenchymal transition; ER overload response; establishment and/or maintenance of cell polarity; establishment of cell polarity; fat cell differentiation; genetic imprinting; glycogen metabolic process; hippocampus development; insulin receptor signaling pathway; myoblast fusion; myotube differentiation; negative regulation of apoptosis; negative regulation of cardiac muscle hypertrophy; negative regulation of dendrite development; negative regulation of dendrite morphogenesis; negative regulation of dopaminergic neuron differentiation; negative regulation of MAP kinase activity; negative regulation of neuron death; negative regulation of neuron maturation; negative regulation of neuron migration; negative regulation of neuron projection development; negative regulation of NFAT protein import into nucleus; negative regulation of nitric-oxide synthase activity; negative regulation of protein binding; negative regulation of protein complex assembly; negative regulation of protein localization to centrosome; negative regulation of protein localization to nucleus; negative regulation of smooth muscle cell apoptotic process; negative regulation of TOR signaling; neuron projection development; organ morphogenesis; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation; phosphorylation; positive regulation of apoptosis; positive regulation of autophagy; positive regulation of axon extension; positive regulation of cardiac muscle cell differentiation; positive regulation of cell-matrix adhesion; positive regulation of DNA biosynthetic process; positive regulation of excitatory postsynaptic potential; positive regulation of gene expression; positive regulation of GTPase activity; positive regulation of mitochondrial membrane potential; positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; positive regulation of mitochondrion organization; positive regulation of neuron apoptotic process; positive regulation of neuron death; positive regulation of peptidyl-serine phosphorylation; positive regulation of peptidyl-threonine phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of protein binding; positive regulation of protein catabolic process; positive regulation of protein complex assembly; positive regulation of protein export from nucleus; positive regulation of smooth muscle cell proliferation; positive regulation of stem cell differentiation; positive regulation of transcription from RNA polymerase II promoter; protein amino acid phosphorylation; protein autophosphorylation; protein export from nucleus; re-entry into mitotic cell cycle; regulation of axon extension; regulation of axonogenesis; regulation of dendrite morphogenesis; regulation of microtubule-based process; regulation of neuron projection development; regulation of neuronal synaptic plasticity; response to activity; response to drug; response to epinephrine; response to estradiol; response to insulin stimulus; response to insulin-like growth factor stimulus; response to L-glutamate; response to lithium ion; response to ultrasound; superior temporal gyrus development; Wnt receptor signaling pathway through beta-catenin; Wnt signaling pathway