Low-Density Lipoprotein-Receptor-Related Protein 1 (LRP-1) ELISA Kit for Human

This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015]

LRP1: a receptor involved in endocytosis, phagocytosis of apoptotic cells, and neural signaling. Modulates cellular events including APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling and neurotransmission. Involved in the plasma clearance of chylomicron remnants and activated alpha 2-macroglobulin, as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Plays a fundamental role in cellular signaling pathways in the brain. Mediates neural NMDA gating via a complex of LRP1, PSD-95 and NMDAR. A type I membrane protein. After cleavage, the intracellular domain (LRPICD) is detected both in the cytoplasm and in the nucleus. Most abundant in liver, brain and lung.

Protein type: Cell surface; Membrane protein, integral; Motility/polarity/chemotaxis; Receptor, misc.

Chromosomal Location of Human Ortholog: 12q13.3

Cellular Component: basolateral plasma membrane; cell soma; clathrin-coated pit; clathrin-coated vesicle; cytosol; dendrite; early endosome; focal adhesion; integral component of plasma membrane; lysosomal membrane; membrane; nucleolus; plasma membrane; plasma membrane protein complex; receptor complex

Molecular Function: alpha-2 macroglobulin receptor activity; apolipoprotein binding; apolipoprotein receptor activity; calcium ion binding; clathrin heavy chain binding; heparan sulfate proteoglycan binding; lipoprotein particle receptor binding; lipoprotein transporter activity; low-density lipoprotein receptor activity; protease binding; protein binding; protein complex binding; receptor activity; RNA binding; scavenger receptor activity

Biological Process: aging; apoptotic cell clearance; astrocyte activation during immune response; cell proliferation; cellular response to amyloid-beta; cerebral cortex development; lipid metabolic process; lipoprotein metabolic process; lipoprotein transport; negative regulation of neuron apoptosis; negative regulation of neuron projection development; negative regulation of platelet-derived growth factor receptor-beta signaling pathway; negative regulation of smooth muscle cell migration; negative regulation of Wnt signaling pathway; phagocytosis; positive regulation of amyloid-beta clearance; positive regulation of cell death; positive regulation of cholesterol efflux; positive regulation of endocytosis; positive regulation of lipid transport; positive regulation of lysosomal protein catabolic process; positive regulation of protein binding; positive regulation of protein catabolic process; positive regulation of protein transport; protein kinase C-activating G-protein coupled receptor signaling pathway; receptor internalization; receptor-mediated endocytosis; regulation of actin cytoskeleton organization; regulation of cholesterol transport; regulation of extracellular matrix disassembly; regulation of phospholipase A2 activity; regulation of protein metabolic process; retinoid metabolic process; transcytosis

Disease: Keratosis Pilaris Atrophicans