DNA-Binding Protein Inhibitor Id-2 (ID2) ELISA Kit for Rat

ID2: ID (inhibitor of DNA binding) HLH proteins lack a basic DNA-binding domain but are able to form heterodimers with other HLH proteins, thereby inhibiting DNA binding. ID-2 may be an inhibitor of tissue-specific gene expression. Heterodimer with other HLH proteins. Interacts with GATA4, IFI204 and NKX2-5. Interacts with NR0B2. Highly expressed in early fetal tissues, including those of the central nervous system.

Protein type: DNA-binding; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 6q16

Cellular Component: chromatin; cytoplasm; cytosol; nucleus; protein complex

Molecular Function: ion channel binding; protein binding; protein dimerization activity; protein heterodimerization activity

Biological Process: adult locomotory behavior; bundle of His development; cell development; cell maturation; cell morphogenesis involved in neuron differentiation; cellular response to lithium ion; cellular senescence; circadian regulation of gene expression; circadian rhythm; embryonic digestive tract morphogenesis; entrainment of circadian clock; entrainment of circadian clock by photoperiod; enucleate erythrocyte differentiation; heart development; leukocyte differentiation; locomotor rhythm; mammary gland epithelial cell proliferation; membranous septum morphogenesis; metanephros development; natural killer cell differentiation; negative regulation of B cell differentiation; negative regulation of DNA binding; negative regulation of gene expression; negative regulation of neural precursor cell proliferation; negative regulation of neuron differentiation; negative regulation of oligodendrocyte differentiation; negative regulation of osteoblast differentiation; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; neuron differentiation; neuron fate commitment; olfactory bulb development; oligodendrocyte development; Peyer's patch development; positive regulation of astrocyte differentiation; positive regulation of blood pressure; positive regulation of cell cycle; positive regulation of cell cycle arrest; positive regulation of cell proliferation; positive regulation of erythrocyte differentiation; positive regulation of fat cell differentiation; positive regulation of gene expression; positive regulation of macrophage differentiation; positive regulation of smooth muscle cell proliferation; positive regulation of transcription, DNA-templated; regulation of circadian rhythm; regulation of G1/S transition of mitotic cell cycle; regulation of lipid metabolic process; thigmotaxis; transcription, DNA-dependent