B-Cell Leukemia/Lymphoma 2 (BCL-2) ELISA Kit for Rabbit

This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Bcl-11A: Functions as a myeloid and B-cell proto-oncogene. May play important roles in leukemogenesis and hematopoiesis. An essential factor in lymphopoiesis, is required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of ARP1. Chromosomal aberrations involving BCL11A may be a cause of lymphoid malignancies. Translocation t(2;14)(p13;q32.3) causes BCL11A deregulation and amplification. 6 isoforms of the human protein are produced by alternative splicing.

Protein type: Nuclear receptor co-regulator; C2H2-type zinc finger protein; Transcription, coactivator/corepressor

Chromosomal Location of Human Ortholog: 2p16.1

Cellular Component: cytoplasm; nucleoplasm; nucleus

Molecular Function: metal ion binding; protein binding; protein heterodimerization activity; protein homodimerization activity; transcription corepressor activity

Biological Process: B cell differentiation; negative regulation of axon extension; negative regulation of collateral sprouting; negative regulation of protein homooligomerization; negative regulation of transcription from RNA polymerase II promoter; positive regulation of collateral sprouting; positive regulation of transcription from RNA polymerase II promoter; protein sumoylation; regulation of dendrite development; signal transduction; T cell differentiation; transcription from RNA polymerase II promoter