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Vimentin (VIM) Human Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS286128

Vimentin is a type III intermediate filament (IF) protein that is expressed in mesenchymal cells. IF proteins are found in all metazoan cells as well as bacteria. IF, along with tubulin-based microtubules and actin-based microfilaments, comprise the… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Vimentin, Recombinant Protein
Full Product Name
Recombinant Human Vimentin Protein
Product Gene Name
VIM recombinant protein
Product Synonym Names
FLJ36605; OTTHUMP00000019224; VIME_HUMAN.
Sequence
STRSVSSSSY RRMFGGPGTA SRPSSSRSYV TTSTRTYSLG SALRPSTSRS LYASSPGGVY ATRSSAVRLR SSVPGVRLLQ DSVDFSLADA INTEFKNTRT NEKVELQELN DRFANYIDKV RFLEQQNKIL LAELEQLKGQ GKSRLGDLYE EEMRELRRQV DQLTNDKARV EVERDNLAED IMRLREKLQE EMLQREEAEN TLQSFRQDVD NASLARLDLE RKVESLQEEI AFLKKLHEEE IQELQAQIQE QHVQIDVDVS KPDLTAALRD VRQQYESVAA KNLQEAEEWY KSKFADLSEA ANRNNDALRQ AKQESTEYRR QVQSLTCEVD ALKGTNESLE RQMREMEENF AVEAANYQDT IGRLQDEIQN MKEEMARHLR EYQDLLNVKM ALDIEIATYR KLLEGEESRI SLPLPNFSSL NLRETNLDSL PLVDTHSKRT LLIKTVETRD GQVINETSQH HDDLE
Host
E. coli
Form/Format
10 mM Tris-HCl, 1 mM EDTA, pH 8.0, 50% glycerol.
Purity/Purification
> 90 % as determined by SDS-PAGE.
Concentration
0.8 mg/mL (lot specific)
Preparation and Storage
Store it under sterile conditions at -20°C upon receiving. Recommend to aliquot the protein into smaller quantities for optimal storage.

**Avoid repeated freeze-thaw cycles.**

Stability: The recombinant protein is stable for up to 6 months from date of receipt at -80°C.
Molecular Weight
Predicted MW: 57.5 kDa
Observed MW: 58 kDa
Sequence Positions
AA 2-466
OMIM
M14144 Genomic DNA
3D Structure
ModBase 3D Structure for P08670
Species
Human
Source
Human
Protein Residues
with N-terminal 6×His-tagged.
Usage
VIM Protein - Centrifuge the standard vial at 6000-10000rpm for 30s.
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for VIM recombinant protein
User determined

SDS-PAGE of VIM recombinant protein

Human VIM Recombinant Protein – Cat# MBS286128

Other Notes

Small volumes of VIM recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for VIM purchase

MBS286128 is a recombinant protein targeting VIM. Also known as Recombinant Human Vimentin Protein. Host: E. coli.

Additional Details

NCBI/Uniprot data below describe general gene information for VIM. It may not necessarily be applicable to this product.

NCBI GI #
62414289
NCBI GeneID
7431
NCBI Accession #
NP_003371.2
UniProt Primary Accession #
P08670
UniProt Secondary Accession #
Q15867; Q15868; Q15869; Q548L2; Q6LER9; Q8N850; Q96ML2; Q9NTM3; B0YJC2; D3DRU4
UniProt Related Accession #
P08670
GenBank Nucleotide #
NM_003380.3
NCBI Official Full Name
vimentin
NCBI Official Synonym Full Names
vimentin
NCBI Official Symbol
VIM
NCBI Official Synonym Symbols
HEL113; CTRCT30
UniProt Protein Name
Vimentin
Protein Family
Vimentin
UniProt Gene Name
VIM
UniProt Entry Name
VIME_HUMAN
NCBI Protein Information
vimentin

NCBI Summary for VIM

This gene encodes a member of the intermediate filament family. Intermediate filamentents, along with microtubules and actin microfilaments, make up the cytoskeleton. The protein encoded by this gene is responsible for maintaining cell shape, integrity of the cytoplasm, and stabilizing cytoskeletal interactions. It is also involved in the immune response, and controls the transport of low-density lipoprotein (LDL)-derived cholesterol from a lysosome to the site of esterification. It functions as an organizer of a number of critical proteins involved in attachment, migration, and cell signaling. Mutations in this gene causes a dominant, pulverulent cataract.[provided by RefSeq, Jun 2009]
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UniProt Comments for VIM

Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally.

Research Articles on VIM

1. Analysis of vimentin and Ki67 expression can straightforwardly be assessed in CTCs from patients with mCRPC. Poorer survival outcomes were observed in vimentin- and Ki67-positive CTC patients.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with VIM recombinant protein

 Reference Product  PubMed Publications
 CASP3 recombinant protein  >8 publications with VIM and CASP3
 AKT1 recombinant protein  >4 publications with VIM and AKT1
 TPM3 recombinant protein  >1 publications with VIM and TPM3
 CASP8 recombinant protein  >1 publications with VIM and CASP8

Pathways associated with VIM recombinant protein

 Products by Pathway  Pathway Diagram
 Allograft Rejection Pathway antibodies  Allograft Rejection Pathway Diagram
 Apoptosis Pathway antibodies  Apoptosis Pathway Diagram
 Apoptosis-related Network Due To Altered Notch3 In Ovarian Cancer Pathway antibodies  Apoptosis-related Network Due To Altered Notch3 In Ovarian Cancer Pathway Diagram
 Apoptotic Cleavage Of Cellular Proteins Pathway antibodies  Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
 Apoptotic Execution Phase Pathway antibodies  Apoptotic Execution Phase Pathway Diagram
 Aurora B Signaling Pathway antibodies  Aurora B Signaling Pathway Diagram
 Caspase Cascade In Apoptosis Pathway antibodies  Caspase Cascade In Apoptosis Pathway Diagram
 Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway antibodies  Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram

Diseases associated with VIM recombinant protein

 Disease Name  Pubmed Publications
 Neurodegenerative Diseases Antibodies  >188 publications with VIM and Neurodegenerative Diseases
 Inflammation Antibodies  >80 publications with VIM and Inflammation
 Disease Models, Animal Antibodies  >49 publications with VIM and Disease Models, Animal
 Kidney Diseases Antibodies  >47 publications with VIM and Kidney Diseases
 Neoplasm Metastasis Antibodies  >45 publications with VIM and Neoplasm Metastasis
 Fibrosis Antibodies  >43 publications with VIM and Fibrosis
 Breast Neoplasms Antibodies  >42 publications with VIM and Breast Neoplasms
 Liver Diseases Antibodies  >40 publications with VIM and Liver Diseases
 Necrosis Antibodies  >29 publications with VIM and Necrosis
 Liver Neoplasms Antibodies  >27 publications with VIM and Liver Neoplasms

Organs/Tissues associated with VIM recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >572 publications with VIM and Brain
 Blood Antibodies  >263 publications with VIM and Blood
 Muscle Antibodies  >137 publications with VIM and Muscle
 Nerve Antibodies  >91 publications with VIM and Nerve
 Bone Antibodies  >89 publications with VIM and Bone
 Kidney Antibodies  >72 publications with VIM and Kidney
 Liver Antibodies  >66 publications with VIM and Liver
 Lung Antibodies  >60 publications with VIM and Lung
 Bone Marrow Antibodies  >55 publications with VIM and Bone Marrow
 Eye Antibodies  >54 publications with VIM and Eye
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