V-Ki-Ras2 Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Antibody – Rabbit Polyclonal

KRas: Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Interacts with PHLPP. Interacts (active GTP-bound form preferentially) with RGS14. Alternate between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase- activating protein (GAP). Belongs to the small GTPase superfamily. Ras family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: G protein; G protein, monomeric; G protein, monomeric, Ras; Motility/polarity/chemotaxis; Oncoprotein

Chromosomal Location of Human Ortholog: 4q44

Cellular Component: cytoplasm; extrinsic to internal side of plasma membrane; focal adhesion; lipid raft; membrane; mitochondrion; plasma membrane

Molecular Function: GDP binding; GMP binding; GTPase activity; LRR domain binding; protein binding; protein complex binding

Biological Process: actin cytoskeleton organization and biogenesis; activation of NF-kappaB transcription factor; cytokine and chemokine mediated signaling pathway; forebrain astrocyte development; homeostasis of number of cells within a tissue; insulin receptor signaling pathway; liver development; negative regulation of cell differentiation; negative regulation of neuron apoptosis; positive regulation of cell proliferation; positive regulation of MAP kinase activity; positive regulation of nitric-oxide synthase activity; positive regulation of protein amino acid phosphorylation; positive regulation of Rac protein signal transduction; Ras protein signal transduction; regulation of long-term neuronal synaptic plasticity; regulation of protein stability; regulation of synaptic transmission, GABAergic; response to glucocorticoid stimulus; response to mineralocorticoid stimulus; striated muscle cell differentiation; visual learning