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Eukaryotic Translation Initiation Factor 4e (EIF4E) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS286438

MBS286438 is an antibody targeting EIF4E. Also known as Rabbit anti-human Eukaryotic translation initiation factor 4E (EIF4E) Polyclonal antibody. Reactive in Human. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
Eukaryotic translation initiation factor 4E (EIF4E), Polyclonal Antibody
Full Product Name
Rabbit anti-human Eukaryotic translation initiation factor 4E (EIF4E) Polyclonal antibody
Product Gene Name
anti-EIF4E antibody
Product Synonym Names
4EBP1; BP-1; PHAS-I; Phosphorylated Heat And Acid-Stable Protein Regulated By Insulin 1
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
Lyophilized or Liquid
Purity/Purification
>=90% by SDS-PAGE
Concentration
1 mg/mL (lot specific)
Molecular Weight
25,053 Da
3D Structure
ModBase 3D Structure for P63074
Immunogen
Recombinant human Eukaryotic translation initiation factor 4E (EIF4E)
ISO Certification
Manufactured in an ISO 9001:2015 Certified Laboratory.
Applications Tested/Suitable for anti-EIF4E antibody
SDS-PAGE; Western Blot (WB); ELISA (EIA)

Other Notes

Small volumes of anti-EIF4E antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for EIF4E. It may not necessarily be applicable to this product.

NCBI GI #
16758870
NCBI GeneID
117045
NCBI Accession #
NP_446426.1
UniProt Primary Accession #
P63074
UniProt Secondary Accession #
P20415
UniProt Related Accession #
P63074
GenBank Nucleotide #
NM_053974.2
NCBI Official Full Name
eukaryotic translation initiation factor 4E
NCBI Official Synonym Full Names
eukaryotic translation initiation factor 4E
NCBI Official Symbol
Eif4e
UniProt Protein Name
Eukaryotic translation initiation factor 4E
UniProt Synonym Protein Names
eIF-4F 25 kDa subunit; mRNA cap-binding protein
Protein Family
Eukaryotic translation initiation factor
UniProt Gene Name
Eif4e
UniProt Synonym Gene Names
eIF-4E; eIF4E
NCBI Protein Information
eukaryotic translation initiation factor 4E

NCBI Summary for EIF4E

binds to the mRNA 7-methylguanosine cap and mediates mRNA binding to the 40S ribosome in the rate limiting step in translational initiation [RGD, Feb 2006]

UniProt Comments for EIF4E

EIF4E: a protein of the eukaryotic initiation factor 4E family. Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. Phosphorylation increases the ability of the protein to bind to mRNA caps and to form the EIF4F complex.

Protein type: Translation; Translation initiation

Chromosomal Location of Human Ortholog: 2q44

Cellular Component: cytoplasm; eukaryotic translation initiation factor 4F complex; mRNA cap complex; perinuclear region of cytoplasm; protein complex; stress granule

Molecular Function: enzyme binding; eukaryotic initiation factor 4G binding; protein binding; translation initiation factor activity

Biological Process: behavioral fear response; G1/S transition of mitotic cell cycle; lung development; negative regulation of neuron differentiation; negative regulation of translation; positive regulation of mitotic cell cycle; regulation of translation; stem cell maintenance
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Research Articles on EIF4E

1. Cerebral ischemia and subsequent reperfusion induced dephosphorylation and phosphorylation of 4E-BP2 at Thr37/Thr46. The induced phosphorylation coincided with the release of 4E-BP2 from eIF4E, although two phosphorylated 4E-BP2 forms were bound to eIF4E.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-EIF4E antibody

 Products by Pathway  Pathway Diagram
 Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway antibodies  Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway Diagram
 Alpha6-Beta4 Integrin Signaling Pathway antibodies  Alpha6-Beta4 Integrin Signaling Pathway Diagram
 Cap-dependent Translation Initiation Pathway antibodies  Cap-dependent Translation Initiation Pathway Diagram
 Deadenylation Of MRNA Pathway antibodies  Deadenylation Of MRNA Pathway Diagram
 Deadenylation-dependent MRNA Decay Pathway antibodies  Deadenylation-dependent MRNA Decay Pathway Diagram
 Eukaryotic Translation Initiation Pathway antibodies  Eukaryotic Translation Initiation Pathway Diagram
 Formation And Maturation Of MRNA Transcript Pathway antibodies  Formation And Maturation Of MRNA Transcript Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Hypertrophy Model Pathway antibodies  Hypertrophy Model Pathway Diagram
 IL-2 Signaling Pathway antibodies  IL-2 Signaling Pathway Diagram

Diseases associated with anti-EIF4E antibody

 Disease Name  Pubmed Publications
 Kidney disorder involving deposition of calcium and oxalate or phosphate in the renal tubules Antibodies  >2426 publications with EIF4E and Kidney disorder involving deposition of calcium and oxalate or phosphate in the renal tubules
 Neoplasms Antibodies  >444 publications with EIF4E and Neoplasms
 Carcinoma Antibodies  >148 publications with EIF4E and Carcinoma
 Cell Transformation, Neoplastic Antibodies  >87 publications with EIF4E and Cell Transformation, Neoplastic
 Breast Neoplasms Antibodies  >74 publications with EIF4E and Breast Neoplasms
 Leukemia Antibodies  >68 publications with EIF4E and Leukemia
 Adenocarcinoma Antibodies  >56 publications with EIF4E and Adenocarcinoma
 Tuberous Sclerosis Antibodies  >52 publications with EIF4E and Tuberous Sclerosis
 Head and Neck Neoplasms Antibodies  >46 publications with EIF4E and Head and Neck Neoplasms
 Hypertrophy Antibodies  >43 publications with EIF4E and Hypertrophy

Organs/Tissues associated with anti-EIF4E antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >98 publications with EIF4E and Liver
 Brain Antibodies  >95 publications with EIF4E and Brain
 Heart Antibodies  >75 publications with EIF4E and Heart
 Kidney Antibodies  >61 publications with EIF4E and Kidney
 Lung Antibodies  >60 publications with EIF4E and Lung
 Pancreas Antibodies  >31 publications with EIF4E and Pancreas
 Ovary Antibodies  >28 publications with EIF4E and Ovary
 Prostate Antibodies  >24 publications with EIF4E and Prostate
 Embryonic Tissue Antibodies  >18 publications with EIF4E and Embryonic Tissue
 Connective Tissue Antibodies  >14 publications with EIF4E and Connective Tissue
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