C-C Chemokine Receptor Type 2 (CCR2) Human Recombinant Protein

This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. [provided by RefSeq, Mar 2009]

CCR2: a seven transmembrane protein closely related to CCR1. Receptor for the MCP-1, MCP-3 and MCP-4 chemokines. Expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. Transduces a signal by increasing the intracellular calcium ions level. Alternative co receptor with CD4 for HIV-1 infection. Two splice-variant isoforms have been described.

Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 3p21.31

Cellular Component: cell soma; cytoplasm; cytosol; dendrite; integral to membrane; integral to plasma membrane; perikaryon; perinuclear region of cytoplasm; plasma membrane

Molecular Function: CCR2 chemokine receptor binding; chemokine receptor activity; protein homodimerization activity

Biological Process: blood vessel remodeling; cellular calcium ion homeostasis; cellular defense response; cellular homeostasis; chemotaxis; cytokine and chemokine mediated signaling pathway; dendritic cell chemotaxis; elevation of cytosolic calcium ion concentration; JAK-STAT cascade; negative regulation of adenylate cyclase activity; negative regulation of angiogenesis; negative regulation of eosinophil degranulation; negative regulation of T-helper 2 type immune response; positive regulation of alpha-beta T cell proliferation; positive regulation of inflammatory response; positive regulation of interferon-gamma production; positive regulation of interleukin-2 production; positive regulation of T cell activation; positive regulation of T-helper 1 type immune response; positive regulation of tumor necrosis factor biosynthetic process; response to wounding