Fermitin Family Homolog 3 (FERMT3) ELISA Kit for Mouse

Name: Mouse FERMT3 ELISA Kit; Fermitin Family Homolog 3; MyBioSource
Brand: MyBioSource
SKU: MBS288399
Price: 405 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS288399

Principle of the Assay: The microtiter plate provided in this kit has been pre-coated with an antibody specific to Fermitin family homolog 3. Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated polyclonal… More details

$405 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

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Product Overview

Online Datasheet in PDF

Product Name

Fermitin family homolog 3 (Fermt3), ELISA Kit

Full Product Name

Mouse Fermitin family homolog 3 ELISA Kit

Product Gene Name

Fermt3 elisa kit

Species Reactivity

Mouse

Assay Type

Sandwich

Detection Range

0.156-10 ng/mL

Sensitivity

0.084 ng/mL

Specificity

This assay recognizes recombinant and natural mouse Fermitin family homolog 3. No significant cross-reactivity or interference was observed.

Preparation and Storage

For long term storage, please store the entire kit at -20 degree C.

Molecular Weight

75,635 Da

3D Structure

ModBase 3D Structure for Q8K1B8

Intra-Assay CV

<=3.2%

Inter-Assay CV

<=7.4%

Recovery

101%

Other Notes

Small volumes of Fermt3 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Fermt3 purchase

MBS288399 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Fermitin family homolog 3 (Fermt3) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing Fermt3. The ELISA analytical biochemical technique of the MBS288399 kit is based on Fermt3 antibody-Fermt3 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect Fermt3 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, Fermt3. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for Fermt3. It may not necessarily be applicable to this product.

NCBI GI #

24418903

NCBI GeneID

108101

NCBI Accession #

NP_722490.1

UniProt Primary Accession #

Q8K1B8

UniProt Related Accession #

Q8K1B8

GenBank Nucleotide #

NM_153795.2

NCBI Official Full Name

fermitin family homolog 3

NCBI Official Synonym Full Names

fermitin family member 3

NCBI Official Symbol

Fermt3

NCBI Official Synonym Symbols

C79673; Kindlin3

UniProt Protein Name

Fermitin family homolog 3

UniProt Synonym Protein Names

Kindlin-3; Unc-112-related protein 2

Protein Family

Fermitin family

UniProt Gene Name

Fermt3

UniProt Synonym Gene Names

Kind3; Urp2

UniProt Entry Name

URP2_MOUSE

NCBI Protein Information

fermitin family homolog 3

UniProt Comments for Fermt3

kindlin-3: Plays a central role in cell adhesion in hematopoietic cells. Acts by activating the integrin beta-1-3 (ITGB1, ITGB2 and ITGB3). Required for integrin-mediated platelet adhesion and leukocyte adhesion to endothelial cells. Required for activation of integrin beta-2 (ITGB2) in polymorphonuclear granulocytes (PMNs). Defects in FERMT3 are the cause of leukocyte adhesion deficiency type 3 (LAD3); also called leukocyte adhesion deficiency 1 variant (LAD1v). LAD3 is a rare syndrome characterized by infections without pus formation in the presence of a leukocytosis combined with a Glanzmann-type bleeding disorder, resulting from a hematopoietic defect in integrin activation. Symptoms arise from an inability to activate the integrins expressed on hematopoietic cells, including platelets and leukocytes. Belongs to the kindlin family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Cell adhesion

Cellular Component: cell junction; cell projection; membrane; podosome

Molecular Function: integrin binding; protein binding

Biological Process: cell adhesion; integrin activation; integrin-mediated signaling pathway; leukocyte adhesion; positive regulation of cell migration; regulation of cell-cell adhesion mediated by integrin

Research Articles on Fermt3

1. The accumulation of HSPCs in the circulation of leukocyte adhesion deficiency type III patients, who lack Kindlin-3, underlines the conserved functions of Kindlin-3 in man and the importance of our findings for human disease.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Fermt3 elisa kit

Reference Product	PubMed Publications
Itgb3 elisa kit	>1 publications with Fermt3 and Itgb3
Itga2b elisa kit	>1 publications with Fermt3 and Itga2b

Pathways associated with Fermt3 elisa kit

Products by Pathway	Pathway Diagram
Platelet Activation Pathway antibodies	Platelet Activation Pathway Diagram

Diseases associated with Fermt3 elisa kit

Disease Name	Pubmed Publications
Osteopetrosis Antibodies	>3 publications with Fermt3 and Osteopetrosis
Inflammation Antibodies	>2 publications with Fermt3 and Inflammation
Hypertrophy Antibodies	>1 publications with Fermt3 and Hypertrophy
Fibrosis Antibodies	>1 publications with Fermt3 and Fibrosis
Neoplasm Metastasis Antibodies	>1 publications with Fermt3 and Neoplasm Metastasis
Liver Diseases Antibodies	>1 publications with Fermt3 and Liver Diseases
Atherosclerosis Antibodies	>1 publications with Fermt3 and Atherosclerosis
Leukocyte Adhesion Deficiency, Type III Antibodies	>1 publications with Fermt3 and Leukocyte Adhesion Deficiency, Type III
Disease Models, Animal Antibodies	>1 publications with Fermt3 and Disease Models, Animal
Hepatomegaly Antibodies	>1 publications with Fermt3 and Hepatomegaly

Organs/Tissues associated with Fermt3 elisa kit

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>14 publications with Fermt3 and Blood
Other Antibodies	>6 publications with Fermt3 and Other
Bone Antibodies	>5 publications with Fermt3 and Bone
Bone Marrow Antibodies	>4 publications with Fermt3 and Bone Marrow
Heart Antibodies	>2 publications with Fermt3 and Heart
Adipose Tissue Antibodies	>1 publications with Fermt3 and Adipose Tissue
Ovary Antibodies	>1 publications with Fermt3 and Ovary
Skin Antibodies	>1 publications with Fermt3 and Skin