Disabled Homolog 1 (DAB1) ELISA Kit for Mouse

DAB1: an adaptor molecule functioning in neural development. The laminar organization of multiple neuronal types in the cerebral cortex is required for normal cognitive function. In mice, the disabled-1 gene plays a central role in brain development, directing the migration of cortical neurons past previously formed neurons to reach their proper layer. Thought to be a signal transducer that interacts with protein kinase pathways to regulate neuronal positioning in the developing brain. Associates with the SH2 domains of Src, Fyn and Abl. Phosphorylated in response to reelin induction in embryonic neurons

Protein type: Adaptor/scaffold

Cellular Component: apical part of cell; brush border; cell soma; cytosol; intracellular; intracellular membrane-bound organelle; membrane; microtubule organizing center; neuron projection; nucleolus; perinuclear region of cytoplasm; postsynaptic density

Molecular Function: phosphoinositide 3-kinase binding; phospholipid binding; protein binding; SH2 domain binding

Biological Process: adult walking behavior; cell differentiation; cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration; central nervous system development; cerebellum structural organization; cerebral cortex cell migration; cerebral cortex radially oriented cell migration; dendrite development; Golgi localization; multicellular organismal development; negative regulation of astrocyte differentiation; negative regulation of axonogenesis; negative regulation of cell adhesion; negative regulation of JAK-STAT cascade; nervous system development; neuron migration; positive regulation of neuron differentiation; positive regulation of protein kinase activity; radial glia guided migration of Purkinje cell; small GTPase mediated signal transduction