Protein Jagged-1 (JAG1) ELISA Kit for Human

Name: Human JAG1 ELISA Kit; Protein Jagged-1; MyBioSource
Brand: MyBioSource
SKU: MBS288900
Price: 405 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS288900

Intended Uses: This immunoassay kit allows for the in vitro quantitative determination ofhumanhJ1concentrations in serum, Plasma,tissue homogenates and Cell culture supernates and Other biological fluids.Principle of the Assay||The microtiter plate provided… More details

$405 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

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Product Overview

Online Datasheet in PDF

Product Name

Protein jagged-1 (JAG1), ELISA Kit

Full Product Name

Human Protein jagged-1 ELISA Kit

Product Gene Name

JAG1 elisa kit

Product Synonym Names

Protein jagged-1; Jagged1; hJ1; JAG1; JAGL1; CD339

Species Reactivity

Human

Assay Type

Sandwich

Detection Range

0.156-10 ng/mL

Sensitivity

0.082 ng/mL

Specificity

This assay recognizes recombinant and natural humanhJ1. No significant cross-reactivity or interference was observed.

Preparation and Storage

For long term storage, please store the entire kit at -20 degree C.

Molecular Weight

116,579 Da

OMIM

118450

3D Structure

ModBase 3D Structure for P78504

Intra-Assay CV

<=6.9%

Inter-Assay CV

<=8.8%

Recovery

90%

Other Notes

Small volumes of JAG1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for JAG1 purchase

MBS288900 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Protein jagged-1 (JAG1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing JAG1. The ELISA analytical biochemical technique of the MBS288900 kit is based on JAG1 antibody-JAG1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect JAG1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, JAG1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for JAG1. It may not necessarily be applicable to this product.

NCBI GI #

4557679

NCBI GeneID

182

NCBI Accession #

NP_000205.1

UniProt Primary Accession #

P78504

UniProt Secondary Accession #

O14902; O15122; Q15816; A0AV43; B4DYR1; E9PCF9

UniProt Related Accession #

P78504

GenBank Nucleotide #

NM_000214.2

NCBI Official Full Name

protein jagged-1

NCBI Official Synonym Full Names

jagged 1

NCBI Official Symbol

JAG1

NCBI Official Synonym Symbols

AGS; AHD; AWS; HJ1; CD339; JAGL1

UniProt Protein Name

Protein jagged-1

UniProt Synonym Protein Names

CD_antigen: CD339

Protein Family

Protein jagged

UniProt Gene Name

JAG1

UniProt Synonym Gene Names

JAGL1; Jagged1; hJ1

UniProt Entry Name

JAG1_HUMAN

NCBI Protein Information

protein jagged-1

NCBI Summary for JAG1

The jagged 1 protein encoded by JAG1 is the human homolog of the Drosophilia jagged protein. Human jagged 1 is the ligand for the receptor notch 1, the latter a human homolog of the Drosophilia jagged receptor notch. Mutations that alter the jagged 1 protein cause Alagille syndrome. Jagged 1 signalling through notch 1 has also been shown to play a role in hematopoiesis. [provided by RefSeq, Jul 2008]

UniProt Comments for JAG1

JAG1: Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation. Enhances fibroblast growth factor-induced angiogenesis (in vitro). Interacts with NOTCH2 and NOTCH3. Interacts with NOTCH1 (in the presence of calcium ions). Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a which supports the long-term maintenance of immature progenitor cells.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 20p12.1-p11.23

Cellular Component: adherens junction; apical plasma membrane; extracellular region; integral to plasma membrane; membrane; plasma membrane

Molecular Function: calcium ion binding; growth factor activity; Notch binding; protein binding; structural molecule activity

Biological Process: angiogenesis; auditory receptor cell differentiation; blood vessel remodeling; cell fate determination; endothelial cell differentiation; hemopoiesis; keratinocyte differentiation; morphogenesis of an epithelial sheet; myoblast differentiation; negative regulation of fat cell differentiation; negative regulation of neuron differentiation; nervous system development; Notch receptor processing; Notch signaling pathway; positive regulation of myeloid cell differentiation; positive regulation of Notch signaling pathway; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; regulation of cell migration; regulation of cell proliferation; response to muramyl dipeptide; T cell mediated immunity

Disease: Alagille Syndrome 1; Tetralogy Of Fallot

Research Articles on JAG1

1. Jagged1 expression may be used as an independent prognosis factor in patients with glioblastoma

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with JAG1 elisa kit

Reference Product	PubMed Publications
NOTCH1 elisa kit	>116 publications with JAG1 and NOTCH1
DLL1 elisa kit	>44 publications with JAG1 and DLL1
NOTCH3 elisa kit	>43 publications with JAG1 and NOTCH3
NOTCH4 elisa kit	>20 publications with JAG1 and NOTCH4
ADAM10 elisa kit	>2 publications with JAG1 and ADAM10
MIB1 elisa kit	>2 publications with JAG1 and MIB1
UBC elisa kit	>1 publications with JAG1 and UBC

Pathways associated with JAG1 elisa kit

Products by Pathway	Pathway Diagram
Activated NOTCH1 Transmits Signal To The Nucleus Pathway antibodies	Activated NOTCH1 Transmits Signal To The Nucleus Pathway Diagram
Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway antibodies	Constitutive Signaling By NOTCH1 HD Domain Mutants Pathway Diagram
Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway antibodies	Constitutive Signaling By NOTCH1 HD+PEST Domain Mutants Pathway Diagram
Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway antibodies	Constitutive Signaling By NOTCH1 PEST Domain Mutants Pathway Diagram
Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway antibodies	Constitutive Signaling By NOTCH1 T(7;9)(NOTCH1:M1580_K2555) Translocation Mutant Pathway Diagram
Delta-Notch Signaling Pathway antibodies	Delta-Notch Signaling Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
Diseases Of Signal Transduction Pathway antibodies	Diseases Of Signal Transduction Pathway Diagram
NOTCH2 Activation And Transmission Of Signal To The Nucleus Pathway antibodies	NOTCH2 Activation And Transmission Of Signal To The Nucleus Pathway Diagram
Notch Signaling Pathway antibodies	Notch Signaling Pathway Diagram

Diseases associated with JAG1 elisa kit

Disease Name	Pubmed Publications
Alagille Syndrome Antibodies	>138 publications with JAG1 and Alagille Syndrome
Liver Diseases Antibodies	>119 publications with JAG1 and Liver Diseases
Heart Defects, Congenital Antibodies	>114 publications with JAG1 and Heart Defects, Congenital
Facies Antibodies	>35 publications with JAG1 and Facies
Heart Diseases Antibodies	>34 publications with JAG1 and Heart Diseases
Breast Neoplasms Antibodies	>24 publications with JAG1 and Breast Neoplasms
Bone Diseases Antibodies	>20 publications with JAG1 and Bone Diseases
Chromosome Aberrations Antibodies	>19 publications with JAG1 and Chromosome Aberrations
Tetralogy of Fallot Antibodies	>18 publications with JAG1 and Tetralogy of Fallot
Brain Diseases Antibodies	>17 publications with JAG1 and Brain Diseases

Organs/Tissues associated with JAG1 elisa kit

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>64 publications with JAG1 and Blood
Embryonic Tissue Antibodies	>36 publications with JAG1 and Embryonic Tissue
Brain Antibodies	>36 publications with JAG1 and Brain
Kidney Antibodies	>23 publications with JAG1 and Kidney
Lung Antibodies	>15 publications with JAG1 and Lung
Connective Tissue Antibodies	>10 publications with JAG1 and Connective Tissue
Placenta Antibodies	>9 publications with JAG1 and Placenta
Pancreas Antibodies	>9 publications with JAG1 and Pancreas
Intestine Antibodies	>7 publications with JAG1 and Intestine
Prostate Antibodies	>6 publications with JAG1 and Prostate