High Mobility Group Protein HMGI-C (HMGA2) ELISA Kit for Human

This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

HMGA2: Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Interacts with E4F1. Interacts with NEK2. Belongs to the HMGA family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Oncoprotein; DNA-binding

Chromosomal Location of Human Ortholog: 12q15

Cellular Component: nuclear chromosome; nucleoplasm; nucleus

Molecular Function: 5'-deoxyribose-5-phosphate lyase activity; AT DNA binding; DNA bending activity; DNA binding; DNA-(apurinic or apyrimidinic site) lyase activity; DNA-dependent protein kinase activity; nucleosomal DNA binding; protein binding; SMAD binding; transcription factor binding

Biological Process: base-excision repair; cell division; chondrocyte differentiation; chromosome breakage; chromosome condensation; DNA damage response, detection of DNA damage; epithelial to mesenchymal transition; establishment and/or maintenance of chromatin architecture; fat cell differentiation; heterochromatin formation; mesenchymal cell differentiation; mesodermal cell differentiation; mitosis; mitotic cell cycle G2/M transition DNA damage checkpoint; multicellular organismal development; negative regulation of apoptosis; negative regulation of DNA binding; negative regulation of retroviral genome replication; negative regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent; positive regulation of apoptosis; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; regulation of growth; regulation of transcription, DNA-dependent; response to virus; stem cell differentiation; transcription from RNA polymerase II promoter

Disease: Leiomyoma, Uterine