Nuclear Receptor Coactivator 1 (NCOA1) ELISA Kit for Human

The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

SRC-1: a transcriptional coactivator for steroid and nuclear hormone receptors. A member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, and bHLH and PAS domains. Phosphorylated and activated via the mitogen-activated protein kinase pathway. Three alternatively spliced isoforms have been described.

Protein type: Oncoprotein; Transcription, coactivator/corepressor; Acetyltransferase; Nuclear receptor co-regulator; DNA-binding; EC 2.3.1.48

Chromosomal Location of Human Ortholog: 2p23

Cellular Component: cytoplasm; neuron projection; nuclear chromatin; nucleoplasm

Molecular Function: androgen receptor binding; chromatin binding; enzyme binding; estrogen receptor binding; histone acetyltransferase activity; ligand-dependent nuclear receptor binding; ligand-dependent nuclear receptor transcription coactivator activity; nuclear hormone receptor binding; progesterone receptor binding; protein binding; protein complex binding; protein dimerization activity; protein N-terminus binding; retinoid X receptor binding; transcription coactivator activity

Biological Process: androgen receptor signaling pathway; bile acid and bile salt transport; bile acid metabolic process; cellular lipid metabolic process; cellular response to hormone stimulus; cerebellum development; cerebral cortex development; establishment and/or maintenance of chromatin architecture; hippocampus development; hypothalamus development; lactation; male gonad development; male mating behavior; positive regulation of apoptosis; positive regulation of female receptivity; positive regulation of neuron differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter by galactose; positive regulation of transcription, DNA-dependent; response to estradiol stimulus; response to progesterone stimulus; response to retinoic acid; transcription, DNA-dependent