Endothelin-1 Receptor (EDNRA) ELISA Kit for Human

This gene encodes the receptor for endothelin-1, a peptide that plays a role in potent and long-lasting vasoconstriction. This receptor associates with guanine-nucleotide-binding (G) proteins, and this coupling activates a phosphatidylinositol-calcium second messenger system. Polymorphisms in this gene have been linked to migraine headache resistance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

EDNRA: Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRA sub-subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Receptor, GPCR; GPCR, family 1; Motility/polarity/chemotaxis; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 4q31.22

Cellular Component: cytosol; integral to plasma membrane; lipid raft; nuclear membrane; plasma membrane; T-tubule

Molecular Function: endothelin receptor activity; phosphoinositide phospholipase C activity; protein binding

Biological Process: adenylate cyclase activation; aging; artery smooth muscle contraction; cell proliferation; elevation of cytosolic calcium ion concentration; elevation of cytosolic calcium ion concentration during G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); enteric nervous system development; fibroblast proliferation; G-protein coupled receptor protein signaling pathway; glomerular filtration; glucose transport; heart development; histamine secretion; in utero embryonic development; maternal process involved in parturition; negative regulation of apoptosis; negative regulation of cAMP biosynthetic process; neural crest cell development; patterning of blood vessels; penile erection; phospholipase C activation; positive regulation of cell proliferation; positive regulation of inflammatory response; positive regulation of odontogenesis; positive regulation of release of sequestered calcium ion into cytosol; protein kinase C activation; regulation of blood pressure; regulation of epithelial cell proliferation; respiratory gaseous exchange; response to hypoxia; response to lipopolysaccharide; response to morphine; Rho protein signal transduction; sensory perception of pain; signal transduction; smooth muscle cell proliferation; smooth muscle contraction; vasoconstriction

Disease: Mandibulofacial Dysostosis With Alopecia; Migraine With Or Without Aura, Susceptibility To, 1