Lamin-B1 (LMNB1) ELISA Kit for Human

Name: Human LMNB1 ELISA Kit; Lamin-B1; MyBioSource
Brand: MyBioSource
SKU: MBS289109
Price: 405 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS289109

Intended Uses: This immunoassay kit allows for the in vitro quantitative determination of target antigen concentrations in serum, plasma, tissue homogenates, cell culture supernates or other biological fluids.Principle of the Assay: The microtiter plate… More details

$405 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Request Current Manual

Product Overview

Online Datasheet in PDF

Product Name

Lamin-B1 (LMNB1), ELISA Kit

Full Product Name

Human Lamin-B1 ELISA Kit

Product Gene Name

LMNB1 elisa kit

Product Synonym Names

Lamin-B1; LMNB1; LMN2; LMNB

Species Reactivity

Human

Samples

Serum, plasma, tissue homogenates, cell culture supernates or other biological fluids

Detection Range

0.78-50 ng/mL

Sensitivity

< 0.34 ng/mL

Specificity

Recombinant and natural Human Lamin-B1

Preparation and Storage

For long term storage, please store the entire kit at -20 degree C.

Inter-assay Precision

<=10.1%

Intra-assay Precision

<=6.3%

Molecular Weight

66,408 Da

OMIM

150340

3D Structure

ModBase 3D Structure for P20700

Other Notes

Small volumes of LMNB1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LMNB1 purchase

MBS289109 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Lamin-B1 (LMNB1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing LMNB1. The ELISA analytical biochemical technique of the MBS289109 kit is based on LMNB1 antibody-LMNB1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect LMNB1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, LMNB1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for LMNB1. It may not necessarily be applicable to this product.

NCBI GI #

5031877

NCBI GeneID

4001

NCBI Accession #

NP_005564.1

UniProt Primary Accession #

P20700

UniProt Secondary Accession #

Q3SYN7; Q96EI6; B2R6J6

UniProt Related Accession #

P20700

GenBank Nucleotide #

NM_005573.3

NCBI Official Full Name

lamin-B1 isoform 1

NCBI Official Synonym Full Names

lamin B1

NCBI Official Symbol

LMNB1

NCBI Official Synonym Symbols

LMN; ADLD; LMN2; LMNB

UniProt Protein Name

Lamin-B1

Protein Family

Lamin

UniProt Gene Name

LMNB1

UniProt Synonym Gene Names

LMN2; LMNB

UniProt Entry Name

LMNB1_HUMAN

NCBI Protein Information

lamin-B1

NCBI Summary for LMNB1

This gene encodes one of the two B-type lamin proteins and is a component of the nuclear lamina. A duplication of this gene is associated with autosomal dominant adult-onset leukodystrophy (ADLD). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]

UniProt Comments for LMNB1

Lamin B1: nuclear lamins are intermediate filament proteins that constitute the lattice-like matrix at the inner face of the nuclear membrane that underlies the nuclear envelop. The lamins, highly conserved throughout evolution, are encoded by three genes in the human: LMNA, LMNB1, and LMNB2. The A-type lamins (lamin A/C) are developmentally regulated and are generally expressed in differentiated cells. The anchoring of chromatin to the nuclear lamina is involved in the control of gene expression and in DNA replication and repair. During mitosis, the nuclear lamina is reversibly disassembled as the lamin proteins are phosphorylated. B-type lamins are phosphorylated within minutes of engaging the IgM surface receptor of resting splenic B cells. Nuclear lamins are cleaved by caspases during apoptosis.

Protein type: Cytoskeletal

Chromosomal Location of Human Ortholog: 5q23.2

Cellular Component: lamin filament; membrane; nuclear envelope; nuclear inner membrane; nuclear matrix; nuclear membrane; nucleoplasm

Molecular Function: phospholipase binding; structural molecule activity

Biological Process: apoptosis; cell structure disassembly during apoptosis; programmed cell death

Disease: Leukodystrophy, Demyelinating, Adult-onset, Autosomal Dominant

Research Articles on LMNB1

1. An upstream mutation alters LMNB1 gene expression in autosomal dominant adult-onset demyelinating leukodystrophy.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with LMNB1 elisa kit

Reference Product	PubMed Publications
LMNA elisa kit	>17 publications with LMNB1 and LMNA
SYNE1 elisa kit	>1 publications with LMNB1 and SYNE1
CDK1 elisa kit	>1 publications with LMNB1 and CDK1

Pathways associated with LMNB1 elisa kit

Products by Pathway	Pathway Diagram
Apoptosis Pathway antibodies	Apoptosis Pathway Diagram
Apoptotic Cleavage Of Cellular Proteins Pathway antibodies	Apoptotic Cleavage Of Cellular Proteins Pathway Diagram
Apoptotic Execution Phase Pathway antibodies	Apoptotic Execution Phase Pathway Diagram
Breakdown Of The Nuclear Lamina Pathway antibodies	Breakdown Of The Nuclear Lamina Pathway Diagram
Caspase Cascade In Apoptosis Pathway antibodies	Caspase Cascade In Apoptosis Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram
Cell Cycle, Mitotic Pathway antibodies	Cell Cycle, Mitotic Pathway Diagram
Cellular Senescence Pathway antibodies	Cellular Senescence Pathway Diagram
Cellular Responses To Stress Pathway antibodies	Cellular Responses To Stress Pathway Diagram
DNA Damage/Telomere Stress Induced Senescence Pathway antibodies	DNA Damage/Telomere Stress Induced Senescence Pathway Diagram

Diseases associated with LMNB1 elisa kit

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>27 publications with LMNB1 and Nervous System Diseases
Pelizaeus-Merzbacher Disease Antibodies	>7 publications with LMNB1 and Pelizaeus-Merzbacher Disease
Liver Diseases Antibodies	>4 publications with LMNB1 and Liver Diseases
Liver Neoplasms Antibodies	>3 publications with LMNB1 and Liver Neoplasms
Carcinoma, Hepatocellular Antibodies	>3 publications with LMNB1 and Carcinoma, Hepatocellular
Disease Models, Animal Antibodies	>2 publications with LMNB1 and Disease Models, Animal
Inflammation Antibodies	>2 publications with LMNB1 and Inflammation
Neoplasm Metastasis Antibodies	>1 publications with LMNB1 and Neoplasm Metastasis
Nerve Degeneration Antibodies	>1 publications with LMNB1 and Nerve Degeneration
Kidney Diseases Antibodies	>1 publications with LMNB1 and Kidney Diseases

Organs/Tissues associated with LMNB1 elisa kit

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>21 publications with LMNB1 and Brain
Blood Antibodies	>11 publications with LMNB1 and Blood
Skin Antibodies	>7 publications with LMNB1 and Skin
Muscle Antibodies	>6 publications with LMNB1 and Muscle
Bone Antibodies	>5 publications with LMNB1 and Bone
Liver Antibodies	>4 publications with LMNB1 and Liver
Pancreas Antibodies	>1 publications with LMNB1 and Pancreas
Lung Antibodies	>1 publications with LMNB1 and Lung
Intestine Antibodies	>1 publications with LMNB1 and Intestine
Connective Tissue Antibodies	>1 publications with LMNB1 and Connective Tissue