Dihydropteridine Reductase (QDPR) ELISA Kit for Mouse

Name: Mouse QDPR ELISA Kit; Dihydropteridine Reductase; MyBioSource
Brand: MyBioSource
SKU: MBS289110
Price: 405 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS289110

MBS289110 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Dihydropteridine reductase (Qdpr) ELISA Kit target analytes in biological samples. The concentration gradients of the kit… More details

$405 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Request Current Manual

Product Overview

Online Datasheet in PDF

Product Name

Dihydropteridine reductase (Qdpr), ELISA Kit

Full Product Name

Mouse Dihydropteridine reductase ELISA Kit

Product Gene Name

Qdpr elisa kit

Product Synonym Names

Dihydropteridine reductase; HDHPR; Quinoid dihydropteridine reductase; Qdpr; Dhpr; 1.5.1.34

Species Reactivity

Mouse

Preparation and Storage

For long term storage, please store the entire kit at -20 degree C.

Molecular Weight

25,570 Da

3D Structure

ModBase 3D Structure for Q8BVI4

Other Notes

Small volumes of Qdpr elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Qdpr. It may not necessarily be applicable to this product.

NCBI GI #

21312520

NCBI GeneID

110391

NCBI Accession #

NP_077198.1

UniProt Primary Accession #

Q8BVI4

UniProt Secondary Accession #

Q3TT09; Q9D0K4

UniProt Related Accession #

Q8BVI4

GenBank Nucleotide #

NM_024236.2

NCBI Official Full Name

dihydropteridine reductase

NCBI Official Synonym Full Names

quinoid dihydropteridine reductase

NCBI Official Symbol

Qdpr

NCBI Official Synonym Symbols

Dhpr; PKU2; D5Ertd371e; 2610008L04Rik

UniProt Protein Name

Dihydropteridine reductase

UniProt Synonym Protein Names

HDHPR; Quinoid dihydropteridine reductase

Protein Family

Dihydropteridine reductase

UniProt Gene Name

Qdpr

UniProt Synonym Gene Names

Dhpr

UniProt Entry Name

DHPR_MOUSE

NCBI Protein Information

dihydropteridine reductase

UniProt Comments for Qdpr

QDPR: The product of this enzyme, tetrahydrobiopterin (BH-4), is an essential cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases. Defects in QDPR are the cause of BH4-deficient hyperphenylalaninemia type C (HPABH4C); also called dihydropteridine reductase deficiency (DHPR deficiency) or hyperphenylalaninemia tetrahydrobiopterin-deficient due to DHPR deficiency or quinoid dihydropteridine reductase deficiency (QDPR deficiency). HPABH4C is a rare autosomal recessive disorder characterized by hyperphenylalaninemia and severe neurologic symptoms (malignant hyperphenylalaninemia) including axial hypotonia and truncal hypertonia, abnormal thermogenesis, and microcephaly. These signs are attributable to depletion of the neurotransmitters dopamine and serotonin, whose syntheses are controlled by tryptophan and tyrosine hydroxylases that use BH-4 as cofactor. These patients do not respond to phenylalanine- restricted diet. HPABH4C is lethal if untreated. Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Protein type: EC 1.5.1.34; Oxidoreductase; Cofactor and Vitamin Metabolism - folate biosynthesis

Cellular Component: cytoplasm; cytosol; mitochondrion; neuron projection

Molecular Function: 6,7-dihydropteridine reductase activity; oxidoreductase activity; protein homodimerization activity

Biological Process: metabolic process; tetrahydrobiopterin biosynthetic process

Research Articles on Qdpr

1. wide alterations in folate-associated metabolism in the Qdpr(-/-) mice

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Qdpr elisa kit

Reference Product	PubMed Publications
Pah elisa kit	>7 publications with Qdpr and Pah
Pcbd1 elisa kit	>4 publications with Qdpr and Pcbd1
Spr elisa kit	>3 publications with Qdpr and Spr

Pathways associated with Qdpr elisa kit

Products by Pathway	Pathway Diagram
Biopterin Recycling Pathway antibodies	Biopterin Recycling Pathway Diagram
Folate Biosynthesis Pathway antibodies	Folate Biosynthesis Pathway Diagram
Folate Biosynthesis Pathway antibodies	Folate Biosynthesis Pathway Diagram
Histidine, Lysine, Phenylalanine, Tyrosine, Proline And Tryptophan Catabolism Pathway antibodies	Histidine, Lysine, Phenylalanine, Tyrosine, Proline And Tryptophan Catabolism Pathway Diagram
Metabolic Pathways antibodies	Metabolic Pathways Diagram
Metabolism Pathway antibodies	Metabolism Pathway Diagram
Metabolism Of Amino Acids And Derivatives Pathway antibodies	Metabolism Of Amino Acids And Derivatives Pathway Diagram
Phenylalanine And Tyrosine Catabolism Pathway antibodies	Phenylalanine And Tyrosine Catabolism Pathway Diagram

Diseases associated with Qdpr elisa kit

Disease Name	Pubmed Publications
Phenylketonurias Antibodies	>11 publications with Qdpr and Phenylketonurias
HYPERPHENYLALANINEMIA, BH4-DEFICIENT, C Antibodies	>11 publications with Qdpr and HYPERPHENYLALANINEMIA, BH4-DEFICIENT, C
Cognition Disorders Antibodies	>4 publications with Qdpr and Cognition Disorders
Atrophy Antibodies	>1 publications with Qdpr and Atrophy
Abnormalities, Multiple Antibodies	>1 publications with Qdpr and Abnormalities, Multiple
Fibrosis Antibodies	>1 publications with Qdpr and Fibrosis

Organs/Tissues associated with Qdpr elisa kit

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>8 publications with Qdpr and Blood
Brain Antibodies	>6 publications with Qdpr and Brain
Kidney Antibodies	>2 publications with Qdpr and Kidney
Lung Antibodies	>1 publications with Qdpr and Lung
Liver Antibodies	>1 publications with Qdpr and Liver