Beta-Type Platelet-Derived Growth Factor Receptor (PDGFRB) ELISA Kit for Mouse

PDGFRB: a receptor tyrosine kinase of the PDGFR family that binds members of the platelet-derived growth factor family. The identity of the growth factor bound determines whether the functional receptor is a homodimer or a heterodimer, composed of both PDGFR-alpha and -beta. Ligand binding induces receptor dimerization and autophosphorylation, thereby recruiting SH2-containing proteins including Grb2, Src, GAP, PTPN11, PI3 kinase, PLC-gamma and Nck. Regulates cell growth, actin reorganization, migration and differentiation. A variety of myeloproliferative disorders and cancers result from translocations that activate PDGFRbeta by fusion with proteins such as TEL/ETV6, H2, CEV14/TRP11, rabaptin 5, and huntington interacting protein 1. Gleevec treatment of TEL fusions has been successful. Overexpressed in metastatic medulloblastoma. Inhibitors: Gleevec, Sutent.

Protein type: Oncoprotein; EC 2.7.10.1; Protein kinase, TK; Kinase, protein; Membrane protein, integral; Protein kinase, tyrosine (receptor); TK group; PDGFR family

Cellular Component: apical plasma membrane; cell surface; cytoplasm; cytoplasmic vesicle; focal adhesion; integral to membrane; intrinsic to plasma membrane; lysosome; membrane; nucleus; plasma membrane

Molecular Function: ATP binding; kinase activity; nucleotide binding; phosphoinositide 3-kinase binding; platelet-derived growth factor beta-receptor activity; platelet-derived growth factor binding; platelet-derived growth factor receptor activity; platelet-derived growth factor receptor binding; protein binding; protein kinase activity; protein kinase binding; protein-tyrosine kinase activity; receptor binding; signal transducer activity; transferase activity; transmembrane receptor protein tyrosine kinase activity

Biological Process: adrenal gland development; cardiac myofibril assembly; cell migration; chemotaxis; glycosaminoglycan biosynthetic process; hemopoiesis; in utero embryonic development; kidney development; multicellular organismal development; negative regulation of apoptosis; nitrogen compound metabolic process; peptidyl-tyrosine phosphorylation; phosphatidylinositol metabolic process; phosphoinositide-mediated signaling; phosphorylation; platelet-derived growth factor receptor signaling pathway; positive regulation of apoptosis; positive regulation of cell migration; positive regulation of cell proliferation; positive regulation of chemotaxis; positive regulation of collagen biosynthetic process; positive regulation of fibroblast proliferation; positive regulation of MAP kinase activity; positive regulation of mitosis; positive regulation of phosphoinositide 3-kinase activity; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of phosphoprotein phosphatase activity; positive regulation of Rho protein signal transduction; positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; protein amino acid autophosphorylation; protein amino acid phosphorylation; regulation of actin cytoskeleton organization and biogenesis; regulation of peptidyl-tyrosine phosphorylation; signal transduction; skeletal morphogenesis; smooth muscle development; tissue homeostasis; transmembrane receptor protein tyrosine kinase signaling pathway