Cytochrome P450 2c19 (CYP2C19) ELISA Kit for Human

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008]

CYP2C19: Responsible for the metabolism of a number of therapeutic agents such as the anticonvulsant drug S-mephenytoin, omeprazole, proguanil, certain barbiturates, diazepam, propranolol, citalopram and imipramine. Belongs to the cytochrome P450 family.

Protein type: Xenobiotic Metabolism - metabolism by cytochrome P450; EC 1.14.13.80; EC 1.14.13.48; Lipid Metabolism - linoleic acid; Cofactor and Vitamin Metabolism - retinol; Secondary Metabolites Metabolism - limonene and pinene degradation; EC 1.14.13.49; Lipid Metabolism - arachidonic acid; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450

Chromosomal Location of Human Ortholog: 10q24

Cellular Component: endoplasmic reticulum membrane; intracellular membrane-bound organelle

Molecular Function: (S)-limonene 6-monooxygenase activity; (S)-limonene 7-monooxygenase activity; arachidonic acid epoxygenase activity; enzyme binding; heme binding; iron ion binding; monooxygenase activity; oxidoreductase activity; oxygen binding; steroid hydroxylase activity

Biological Process: arachidonic acid metabolic process; drug metabolic process; epoxygenase P450 pathway; exogenous drug catabolic process; heterocycle metabolic process; monoterpenoid metabolic process; steroid metabolic process; xenobiotic metabolic process

Disease: Drug Metabolism, Poor, Cyp2c19-related