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Alpha-2a Adrenergic Receptor (ADRA2A) ELISA Kit for Mouse

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS289545

Principle of the Assay: The microtiter plate provided in this kit has been pre-coated with an antibody specific to target antigen. Standards or samples are then added to the appropriate microtiter plate wells with a biotin-conjugated antibody preparation… More details

$405 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Alpha-2A adrenergic receptor (Adra2a), ELISA Kit
Full Product Name
Mouse Alpha-2A adrenergic receptor ELISA Kit
Product Gene Name
Adra2a elisa kit
Product Synonym Names
Alpha-2A adrenergic receptor; Alpha-2A adrenoreceptor; Alpha-2A adrenoceptor; Alpha-2AAR; Adra2a
Species Reactivity
Mouse
Samples
Serum, plasma, tissue homogenates, cell culture supernates or other biological fluids
Preparation and Storage
For long term storage, please store the entire kit at -20 degree C.
Molecular Weight
48,865 Da
3D Structure
ModBase 3D Structure for Q01338
Intra-Assay CV
<=5.3%
Inter-Assay CV
<=7.5%
Recovery
97%

Typical Testing Data/Standard Curve (for reference only) of Adra2a elisa kit

Mouse ADRA2A ELISA Kit – Cat# MBS289545

Other Notes

Small volumes of Adra2a elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Adra2a purchase

MBS289545 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Alpha-2A adrenergic receptor (Adra2a) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing Adra2a. The ELISA analytical biochemical technique of the MBS289545 kit is based on Adra2a antibody-Adra2a antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect Adra2a antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, Adra2a. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for Adra2a. It may not necessarily be applicable to this product.

NCBI GI #
231460
NCBI GeneID
11551
NCBI Accession #
Q01338.1
UniProt Primary Accession #
Q01338
UniProt Related Accession #
Q01338
NCBI Official Full Name
Alpha-2A adrenergic receptor
NCBI Official Synonym Full Names
adrenergic receptor, alpha 2a
NCBI Official Symbol
Adra2a
NCBI Official Synonym Symbols
Adra-2; Adra-2a; alpha2A; AW122659; alpha2-C10; alpha2A-AR; alpha(2A)AR
UniProt Protein Name
Alpha-2A adrenergic receptor
UniProt Synonym Protein Names
Alpha-2A adrenoreceptor; Alpha-2A adrenoceptor; Alpha-2AAR
Protein Family
Alpha-2A adrenergic receptor
UniProt Gene Name
Adra2a
UniProt Synonym Gene Names
Alpha-2A adrenoceptor; Alpha-2AAR
UniProt Entry Name
ADA2A_MOUSE
NCBI Protein Information
alpha-2A adrenergic receptor

UniProt Comments for Adra2a

ADRA2A: Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2A sub-subfamily.

Protein type: GPCR, family 1; Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass

Cellular Component: cytoplasm; integral to plasma membrane; plasma membrane; receptor complex; synapse

Molecular Function: adrenoceptor activity; alpha-2C adrenergic receptor binding; alpha2-adrenergic receptor activity; epinephrine binding; heterotrimeric G-protein binding; norepinephrine binding; protein heterodimerization activity; protein homodimerization activity; protein kinase binding; thioesterase binding

Biological Process: activation of protein kinase activity; activation of protein kinase B; acute inflammatory response; cell-cell signaling; cellular response to hormone stimulus; DNA replication; fear response; female pregnancy; G-protein coupled receptor protein signaling pathway; glucose homeostasis; negative regulation of calcium ion-dependent exocytosis; negative regulation of cAMP biosynthetic process; negative regulation of insulin secretion; negative regulation of lipid catabolic process; positive regulation of cell migration; positive regulation of cytokine production; positive regulation of epidermal growth factor receptor activity; positive regulation of MAP kinase activity; positive regulation of membrane protein ectodomain proteolysis; positive regulation of vasodilation; thermoception
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Research Articles on Adra2a

1. This study showed that reduced expression of the alpha2A-adrenoceptor (Adra2a) which modulate antidepressant action in hippocampus.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with Adra2a elisa kit

 Reference Product  PubMed Publications
 Rgs4 elisa kit  >9 publications with Adra2a and Rgs4
 P2ry12 elisa kit  >9 publications with Adra2a and P2ry12
 Adcy5 elisa kit  >6 publications with Adra2a and Adcy5
 Cnr1 elisa kit  >3 publications with Adra2a and Cnr1
 Gnai2 elisa kit  >2 publications with Adra2a and Gnai2
 Grm2 elisa kit  >1 publications with Adra2a and Grm2
 Gnai1 elisa kit  >1 publications with Adra2a and Gnai1

Pathways associated with Adra2a elisa kit

 Products by Pathway  Pathway Diagram
 Adrenaline Signalling Through Alpha-2 Adrenergic Receptor Pathway antibodies  Adrenaline Signalling Through Alpha-2 Adrenergic Receptor Pathway Diagram
 Adrenaline,noradrenaline Inhibits Insulin Secretion Pathway antibodies  Adrenaline,noradrenaline Inhibits Insulin Secretion Pathway Diagram
 Adrenoceptors Pathway antibodies  Adrenoceptors Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 G Alpha (i) Signalling Events Pathway antibodies  G Alpha (i) Signalling Events Pathway Diagram
 G Alpha (z) Signalling Events Pathway antibodies  G Alpha (z) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram

Organs/Tissues associated with Adra2a elisa kit

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >3346 publications with Adra2a and Brain
 Kidney Antibodies  >581 publications with Adra2a and Kidney
 Spinal Cord Antibodies  >506 publications with Adra2a and Spinal Cord
 Intestine Antibodies  >278 publications with Adra2a and Intestine
 Adipose Tissue Antibodies  >248 publications with Adra2a and Adipose Tissue
 Pancreas Antibodies  >137 publications with Adra2a and Pancreas
 Stomach Antibodies  >123 publications with Adra2a and Stomach
 Bladder Antibodies  >66 publications with Adra2a and Bladder
 Dorsal Root Ganglion Antibodies  >53 publications with Adra2a and Dorsal Root Ganglion
 Embryonic Tissue Antibodies  >40 publications with Adra2a and Embryonic Tissue
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