Cyclin-Dependent Kinase 4 Inhibitor C (CDKN2C) ELISA Kit for Human

Name: Human CDKN2C ELISA Kit; Cyclin-Dependent Kinase 4 Inhibitor C; MyBioSource
Brand: MyBioSource
SKU: MBS289637
Price: 405 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS289637

MBS289637 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Cyclin-dependent kinase 4 inhibitor C (CDKN2C) ELISA Kit target analytes in biological samples. The concentration gradients of… More details

$405 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

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Product Overview

Online Datasheet in PDF

Product Name

Cyclin-dependent kinase 4 inhibitor C (CDKN2C), ELISA Kit

Full Product Name

Human Cyclin-dependent kinase 4 inhibitor C ELISA Kit

Product Gene Name

CDKN2C elisa kit

Product Synonym Names

Cyclin-dependent kinase 4 inhibitor C; Cyclin-dependent kinase 6 inhibitor; p18-INK4c; p18-INK6; CDKN2C; CDKN6

Species Reactivity

Human

Assay Type

Sandwich

Detection Range

0.156-10 ng/mL

Sensitivity

0.1ng/mL

Preparation and Storage

For long term storage, please store the entire kit at -20 degree C.

Molecular Weight

18,127 Da

OMIM

603369

3D Structure

ModBase 3D Structure for P42773

Intra-Assay CV

<=6.5%

Inter-Assay CV

<=9.8%

Recovery

107%

Other Notes

Small volumes of CDKN2C elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CDKN2C. It may not necessarily be applicable to this product.

NCBI GI #

4502751

NCBI GeneID

1031

NCBI Accession #

NP_001253.1

UniProt Primary Accession #

P42773

UniProt Secondary Accession #

Q8TB83

UniProt Related Accession #

P42773

GenBank Nucleotide #

NM_001262.2

NCBI Official Full Name

cyclin-dependent kinase 4 inhibitor C

NCBI Official Synonym Full Names

cyclin-dependent kinase inhibitor 2C

NCBI Official Symbol

CDKN2C

NCBI Official Synonym Symbols

p18; INK4C; p18-INK4C

UniProt Protein Name

Cyclin-dependent kinase 4 inhibitor C

UniProt Synonym Protein Names

Cyclin-dependent kinase 6 inhibitor; p18-INK4c; p18-INK6

Protein Family

Cyclin-dependent kinase 4 inhibitor

UniProt Gene Name

CDKN2C

UniProt Synonym Gene Names

CDKN6

UniProt Entry Name

CDN2C_HUMAN

NCBI Protein Information

cyclin-dependent kinase 4 inhibitor C

NCBI Summary for CDKN2C

The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to interact with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. Ectopic expression of this gene was shown to suppress the growth of human cells in a manner that appears to correlate with the presence of a wild-type RB1 function. Studies in the knockout mice suggested the roles of this gene in regulating spermatogenesis, as well as in suppressing tumorigenesis. Two alternatively spliced transcript variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]

UniProt Comments for CDKN2C

Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.

Research Articles on CDKN2C

1. this studydemonstrated abundant levels of the critical negative cell-cycle regulators, p27(Kip1), its phosphorylated form, p-p27(S10), p18Ink4c, and GSK-3, in beta-cells of both adult human and mouse pancreatic islets, which contribute to maintenance of beta-cell quiescence.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CDKN2C elisa kit

Reference Product	PubMed Publications
CDKN2A elisa kit	>160 publications with CDKN2C and CDKN2A
CDKN1B elisa kit	>137 publications with CDKN2C and CDKN1B
CDKN1A elisa kit	>117 publications with CDKN2C and CDKN1A
CDK4 elisa kit	>103 publications with CDKN2C and CDK4
CDK6 elisa kit	>75 publications with CDKN2C and CDK6
CCND2 elisa kit	>17 publications with CDKN2C and CCND2
CCND1 elisa kit	>12 publications with CDKN2C and CCND1
E2F1 elisa kit	>7 publications with CDKN2C and E2F1
SP1 elisa kit	>4 publications with CDKN2C and SP1

Pathways associated with CDKN2C elisa kit

Products by Pathway	Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram
Cell Cycle, Mitotic Pathway antibodies	Cell Cycle, Mitotic Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram
Cell Cycle Pathway antibodies	Cell Cycle Pathway Diagram
Cellular Senescence Pathway antibodies	Cellular Senescence Pathway Diagram
Cellular Responses To Stress Pathway antibodies	Cellular Responses To Stress Pathway Diagram
Cyclin D Associated Events In G1 Pathway antibodies	Cyclin D Associated Events In G1 Pathway Diagram
E2F Transcription Factor Network Pathway antibodies	E2F Transcription Factor Network Pathway Diagram
G1 Phase Pathway antibodies	G1 Phase Pathway Diagram
G1 To S Cell Cycle Control Pathway antibodies	G1 To S Cell Cycle Control Pathway Diagram

Diseases associated with CDKN2C elisa kit

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>36 publications with CDKN2C and Nervous System Diseases
Cell Transformation, Neoplastic Antibodies	>21 publications with CDKN2C and Cell Transformation, Neoplastic
Adenocarcinoma Antibodies	>19 publications with CDKN2C and Adenocarcinoma
Cardiovascular Diseases Antibodies	>17 publications with CDKN2C and Cardiovascular Diseases
Breast Neoplasms Antibodies	>16 publications with CDKN2C and Breast Neoplasms
Disease Models, Animal Antibodies	>16 publications with CDKN2C and Disease Models, Animal
Neoplasms, Experimental Antibodies	>13 publications with CDKN2C and Neoplasms, Experimental
Hyperplasia Antibodies	>13 publications with CDKN2C and Hyperplasia
Liver Diseases Antibodies	>11 publications with CDKN2C and Liver Diseases
Liver Neoplasms Antibodies	>10 publications with CDKN2C and Liver Neoplasms

Organs/Tissues associated with CDKN2C elisa kit

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>42 publications with CDKN2C and Blood
Brain Antibodies	>31 publications with CDKN2C and Brain
Bone Antibodies	>27 publications with CDKN2C and Bone
Bone Marrow Antibodies	>23 publications with CDKN2C and Bone Marrow
Liver Antibodies	>17 publications with CDKN2C and Liver
Pancreas Antibodies	>15 publications with CDKN2C and Pancreas
Muscle Antibodies	>15 publications with CDKN2C and Muscle
Lung Antibodies	>13 publications with CDKN2C and Lung
Kidney Antibodies	>11 publications with CDKN2C and Kidney
Testis Antibodies	>10 publications with CDKN2C and Testis