Kinesin Heavy Chain (KIF5A) ELISA Kit for Human

KIF5A: Microtubule-dependent motor required for slow axonal transport of neurofilament proteins (NFH, NFM and NFL). Defects in KIF5A are the cause of spastic paraplegia autosomal dominant type 10 (SPG10). An inherited degenerative spinal cord disorder characterized by a slow, gradual, progressive weakness and spasticity (stiffness) of the legs. Rate of progression and the severity of symptoms is quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body. Belongs to the kinesin-like protein family. Kinesin subfamily.

Protein type: Microtubule-binding; Motor

Chromosomal Location of Human Ortholog: 12q13.13

Cellular Component: cytosol; kinesin complex; membrane; microtubule; perinuclear region of cytoplasm

Molecular Function: ATP binding; microtubule binding; motor activity; plus-end-directed microtubule motor activity; protein binding

Biological Process: antigen processing and presentation of exogenous peptide antigen via MHC class II; axon guidance; blood coagulation; cytoskeleton-dependent intracellular transport; metabolic process; microtubule-based movement; protein localization; small GTPase mediated signal transduction; synaptic transmission

Disease: Spastic Paraplegia 10, Autosomal Dominant