Hexokinase-3 (HK3) ELISA Kit for Mouse

HK3: a glycolytic enzyme that catalyzes the reaction ATP + D-hexose = ADP + D-hexose 6-phosphate. The first and rate-limiting step in glycosis, a pathway that produces energy in the form of ATP from glucose. An allosteric enzyme inhibited by its product glucose-6-phosphate (Glc-6-P). Acts as a ""glucose sensor"" by trapping glucose inside the cell by catalyzing its phosphorylation to produce Glc-6-P. In vertebrates there are four major glucose-phosphorylating isoenzymes, designated hexokinase I, II, III and IV (glucokinase).

Protein type: Kinase, other; Enzyme, cellular metabolism; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Transferase; Carbohydrate Metabolism - galactose; EC 2.7.1.1; Carbohydrate Metabolism - fructose and mannose; Carbohydrate Metabolism - starch and sucrose; Carbohydrate Metabolism - amino sugar and nucleotide sugar

Cellular Component: cytosol; mitochondrion; protein complex

Molecular Function: ATP binding; catalytic activity; enzyme binding; fructokinase activity; glucokinase activity; glucose binding; hexokinase activity; hormone binding; kinase activity; mannokinase activity; nucleotide binding; phosphotransferase activity, alcohol group as acceptor; transferase activity

Biological Process: carbohydrate metabolic process; carbohydrate phosphorylation; cell glucose homeostasis; glycolysis; metabolic process; phosphorylation