Heterogeneous Nuclear Ribonucleoproteins A2/B1 (HNRNPA2B1) ELISA Kit for Mouse

hnRNP A2/B1: Involved with pre-mRNA processing. Forms complexes (ribonucleosomes) with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Identified in the spliceosome C complex. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with IGF2BP1. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: RNA splicing; Spliceosome; RNA-binding

Cellular Component: cell soma; chromatin; cytoplasm; membrane; neuron projection; nucleoplasm; nucleus; perikaryon; ribonucleoprotein complex; spliceosome

Molecular Function: miRNA binding; mRNA 3'-UTR binding; nucleic acid binding; nucleotide binding; RNA binding; single-stranded telomeric DNA binding

Biological Process: mRNA export from nucleus; mRNA processing; negative regulation of nuclear mRNA splicing, via spliceosome; negative regulation of transcription from RNA polymerase II promoter; nuclear mRNA splicing, via spliceosome; primary microRNA processing; RNA splicing; RNA transport