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SMG7 Antibody – Rabbit

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS002909

MBS002909 is an antibody targeting SMG7. Also known as Rabbit SMG7 Antibody. Reactive in Human. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
SMG7, Antibody
Full Product Name
Rabbit SMG7 Antibody
Product Gene Name
Host
Rabbit
Species Reactivity
Human
Form/Format
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Concentration
1 mg/ml (lot specific)
Molecular Weight
127,282 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (183441506..183523328). Location: 1q25
OMIM
610964
3D Structure
ModBase 3D Structure for Q92540
Applications Tested/Suitable for anti-SMG7 antibody
ELISA (EIA), Immunofluorescence (IF), Western Blot (WB)

Other Notes

Small volumes of anti-SMG7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SMG7. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
protein SMG7 isoform 5
NCBI Official Synonym Full Names
smg-7 homolog, nonsense mediated mRNA decay factor (C. elegans)
NCBI Official Symbol
SMG7
NCBI Official Synonym Symbols
EST1C; SGA56M; C1orf16
UniProt Protein Name
Protein SMG7
UniProt Synonym Protein Names
EST1-like protein C; SMG-7 homolog
Protein Family
UniProt Gene Name
SMG7
UniProt Synonym Gene Names
C1orf16; EST1C; KIAA0250; hSMG-7
UniProt Entry Name
SMG7_HUMAN
NCBI Protein Information
protein SMG7; EST1-like protein C; ever shorter telomeres 1C; EST1 telomerase component homolog C; breast cancer-associated antigen SGA-56M

NCBI Summary for SMG7

This gene encodes a protein that is essential for nonsense-mediated mRNA decay (NMD); a process whereby transcripts with premature termination codons are targeted for rapid degradation by a mRNA decay complex. The mRNA decay complex consists, in part, of this protein along with proteins SMG5 and UPF1. The N-terminal domain of this protein is thought to mediate its association with SMG5 or UPF1 while the C-terminal domain interacts with the mRNA decay complex. This protein may therefore couple changes in UPF1 phosphorylation state to the degradation of NMD-candidate transcripts. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Aug 2011]
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UniProt Comments for SMG7

SMG7: Plays a role in nonsense-mediated mRNA decay. Recruits UPF1 to cytoplasmic mRNA decay bodies. Together with SMG5 is thought to provide a link to the mRNA degradation machinery involving exonucleolytic pathways, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Adaptor/scaffold

Chromosomal Location of Human Ortholog: 1q25

Cellular Component: intermediate filament cytoskeleton; cytoplasm; cytosol; nucleus

Molecular Function: protein binding; protein phosphatase 2A binding

Biological Process: mRNA export from nucleus; mRNA catabolic process, nonsense-mediated decay; regulation of dephosphorylation; gene expression
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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