VTI1A Antibody – Rabbit

VTI1A: V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. Involved in vesicular transport from the late endosomes to the trans-Golgi network. Along with VAMP7, involved in an non- conventional RAB1-dependent traffic route to the cell surface used by KCNIP1 and KCND2. May be involved in increased cytokine secretion associated with cellular senescence. Belongs to the VTI1 family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 10q25.2

Cellular Component: SNARE complex; Golgi membrane; Golgi apparatus; endoplasmic reticulum membrane; synaptic vesicle; Golgi stack; clathrin-coated vesicle; cell soma; perinuclear region of cytoplasm; late endosome membrane; integral to membrane; endosome

Molecular Function: SNAP receptor activity; SNARE binding

Biological Process: intra-Golgi vesicle-mediated transport; voluntary musculoskeletal movement; ER to Golgi vesicle-mediated transport; Golgi to vacuole transport; protein targeting to vacuole; vesicle fusion with Golgi apparatus; retrograde transport, endosome to Golgi

Disease: Multiple Mitochondrial Dysfunctions Syndrome 3