Hamster Anti-TNFR2 Monoclonal Antibody – Cat# MBS3030148

TNFR2 Antibody – Hamster Monoclonal

Name: TNFR2 Antibody; Monoclonal; Hamster; Mouse-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS3030148
Price: 275 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3030148

Tumor necrosis factor receptor II (TNF-RII) is present on most cell types and is considered to play a prominent role in stimulation by TNF-alpha. TNFRII proteins are expressed by hematopoietic cells including macrophages, neutrophils, lymphocytes, thymocytes… More details

$275 / 1 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

TNFR2, Monoclonal Antibody

Full Product Name

Anti-Mouse TNFR2 In Vivo Antibody - Low Endotoxin (TR75-54.7)

Product Gene Name

anti-TNFR2 antibody

Product Synonym Names

Tnfrsf1b; Tumor necrosis factor receptor superfamily member 1B; Tumor necrosis factor receptor 2; TNF-R2; Tumor necrosis factor receptor type II; TNF-RII; TNFR-II; p75; p80 TNF-alpha receptor; CD120b; Tnfr-2

Clonality

Monoclonal

Isotype

Armenian Hamster IgG

Clone Number

TR75-54.7

Host

Armenian Hamster

Species Reactivity

Mouse

Form/Format

0.01 M phosphate buffered saline (PBS) pH 7.2 - 7.4, 150 mM NaCl with no carrier protein, potassium or preservatives added.

Purity/Purification

>95% by SDS-PAGE and HPLC
This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.

Concentration

1.0mg/ml (lot specific)

Specificity

Anti-TNFR2 In Vivo Antibody - Low Endotoxin (TR75-54.7) recognizes Mouse CD120

Preparation and Storage

anti-TNFR2 In Vivo Antibody - Low Endotoxin (TR75-54.7) is stable for at least four (4) weeks when stored sterile at 2-8 degree C. For long-term storage aseptically aliquot in working volumes without diluting and store at -20 degree C in a manual defrost freezer. Avoid Repeated Freeze Thaw Cycles.

Matching Pairs

Antibody: TNFR2 Clone #TR75-54.7 (MBS3030148)
Isotype Control: GST Clone #PIP (MBS3030272)

Molecular Weight

50,320 Da

3D Structure

ModBase 3D Structure for P25119

GMP

Manufactured according to cGMP (Current Good Manufacturing Practice) standards.

Endotoxin

<= 1.0 EU/mg as determined by the LAL method

Immunogen

Purified Recombinant Mouse TNF R2

Aggregation

Aggregation level <= 5%

Product Categories/Family for anti-TNFR2 antibody

Low Endotoxin; anti-mouse

Applications Tested/Suitable for anti-TNFR2 antibody

Immunoprecipitation (IP), Western Blot (WB), Blocking (BL), Flow Cytometry (FC/FACS), ELISA (EIA)

Application Notes for anti-TNFR2 antibody

BL: Clone TR75-54.7 antibody has been reported to block ligand-induced receptor signaling.

Other Notes

Small volumes of anti-TNFR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TNFR2 purchase

MBS3030148 is an antibody targeting TNFR2. Also known as Anti-Mouse TNFR2 In Vivo Antibody - Low Endotoxin (TR75-54.7). Reactive in Mouse. Host: Armenian Hamster.

Additional Details

NCBI/Uniprot data below describe general gene information for TNFR2. It may not necessarily be applicable to this product.

NCBI GI #

70778792

NCBI GeneID

21938

NCBI Accession #

NP_035740.2

UniProt Primary Accession #

P25119

UniProt Secondary Accession #

O88734; P97893

UniProt Related Accession #

P25119

GenBank Nucleotide #

NM_011610.3

NCBI Official Full Name

tumor necrosis factor receptor superfamily member 1B

NCBI Official Synonym Full Names

tumor necrosis factor receptor superfamily, member 1b

NCBI Official Symbol

Tnfrsf1b

NCBI Official Synonym Symbols

p75; TNFBR; Tnfr2; CD120b; TNF-R2; TNFR80; TNFRII; Tnfr-1; TNF-R75; TNF-R-II; TNF-alphaR2; TNFalpha-R2

UniProt Protein Name

Tumor necrosis factor receptor superfamily member 1B

UniProt Synonym Protein Names

Tumor necrosis factor receptor 2; TNF-R2; Tumor necrosis factor receptor type II; TNF-RII; TNFR-II; p75; p80 TNF-alpha receptor; CD_antigen: CD120b

Protein Family

Baculoviral IAP repeat-containing protein

UniProt Gene Name

Tnfrsf1b

UniProt Synonym Gene Names

Tnfr-2; Tnfr2; TNF-R2; TNF-RII; TNFR-II

UniProt Entry Name

TNR1B_MOUSE

NCBI Protein Information

tumor necrosis factor receptor superfamily member 1B; TNF receptor beta chain; TNF-RII; TNFR-II; p75 TNFR; p80 TNF-alpha receptor; tumor necrosis factor receptor 2; tumor necrosis factor receptor type II

UniProt Comments for TNFR2

TNF-R2: Receptor with high affinity for TNFSF2/TNF-alpha and approximately 5-fold lower affinity for homotrimeric TNFSF1/lymphotoxin-alpha. The TRAF1/TRAF2 complex recruits the apoptotic suppressors BIRC2 and BIRC3 to TNFRSF1B/TNFR2. This receptor mediates most of the metabolic effects of TNF-alpha. Isoform 2 blocks TNF-alpha-induced apoptosis, which suggests that it regulates TNF-alpha function by antagonizing its biological activity. Binds to TRAF2. Interacts with BMX. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, cytokine

Cellular Component: membrane; cell soma; axon; perinuclear region of cytoplasm; integral to membrane; intracellular; nucleus; lipid raft

Molecular Function: protein binding; tumor necrosis factor receptor activity; ubiquitin protein ligase binding

Biological Process: cell proliferation; cell surface receptor linked signal transduction; DNA damage response, signal transduction resulting in induction of apoptosis; tumor necrosis factor-mediated signaling pathway; negative regulation of inflammatory response; programmed cell death; immune response; inflammatory response; RNA destabilization; positive regulation of membrane protein ectodomain proteolysis

Research Articles on TNFR2

1. PGRN protection of endoplasmic reticulum stress induced apoptosis was abolished when TNFR2 signaling was blocked.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-TNFR2 antibody

Products by Pathway	Pathway Diagram
Adipocytokine Signaling Pathway antibodies	Adipocytokine Signaling Pathway Diagram
Adipocytokine Signaling Pathway antibodies	Adipocytokine Signaling Pathway Diagram
Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies	Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
Amyotrophic Lateral Sclerosis (ALS) Pathway antibodies	Amyotrophic Lateral Sclerosis (ALS) Pathway Diagram
Apoptosis Pathway antibodies	Apoptosis Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
IL-3 Signaling Pathway antibodies	IL-3 Signaling Pathway Diagram
Inflammatory Response Pathway antibodies	Inflammatory Response Pathway Diagram
Oxidative Damage Pathway antibodies	Oxidative Damage Pathway Diagram

Organs/Tissues associated with anti-TNFR2 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>66 publications with TNFR2 and Blood
Bone Antibodies	>14 publications with TNFR2 and Bone
Lung Antibodies	>9 publications with TNFR2 and Lung
Kidney Antibodies	>8 publications with TNFR2 and Kidney
Skin Antibodies	>6 publications with TNFR2 and Skin
Liver Antibodies	>5 publications with TNFR2 and Liver
Bone Marrow Antibodies	>5 publications with TNFR2 and Bone Marrow
Joint Antibodies	>4 publications with TNFR2 and Joint
Connective Tissue Antibodies	>4 publications with TNFR2 and Connective Tissue
Eye Antibodies	>3 publications with TNFR2 and Eye