• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

Toripalimab (PD-1) Antibody – Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3030365

Pembrolizumab biosimilar is a humanized monoclonal antibody that blocks the interaction between PD-1 and its ligands, PD-L1 and PD-L2. It is an IgG4 kappa immunoglobulin with an approximate molecular weight of 149 kDa. More details

$445 / 1 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Toripalimab (PD-1), Monoclonal Antibody
Full Product Name
Toripalimab Biosimilar - Research Grade
Product Gene Name
anti-PD-1 antibody
Product Synonym Names
Programmed cell death protein 1; Pdcd1; CD279
Clonality
Monoclonal
Isotype
Human IgG4
Host
Humanized
Species Reactivity
Human
Form/Format
Phosphate buffered saline (PBS) pH 7.2,with no carrier protein, potassium or preservatives added. BSA and Azide free.
Purity/Purification
>95% by SDS-PAGE and HPLC
This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Concentration
1.0-5.0mg/ml (lot specific)
Specificity
Detects human PD-1. This non-therapeutic antibody uses the same sequence as the therapeutic antibody Toripalimab.
Preparation and Storage
Stable for at least one week when stored sterile at 2-8 degree C. For long term storage aseptically aliquot in working volumes without diluting and store at -80 degree C. Avoid Repeated Freeze Thaw Cycles.
Matching Pairs
Antibody: PD-1 (MBS3030365)
Isotype Control: IgG4 Clone #IB4 (MBS3030286)
Molecular Weight
31,647 Da
OMIM
L27440 Genomic DNA
3D Structure
ModBase 3D Structure for Q15116
GMP
Manufactured according to cGMP (Current Good Manufacturing Practice) standards.
Endotoxin
<= 0.75 EU/mg as determined by the LAL method

Product Categories/Family for anti-PD-1 antibody

Low endotoxin; biosimilar antibody
Applications Tested/Suitable for anti-PD-1 antibody
Functional Assay (FUNC)

Western Blot (WB) of anti-PD-1 antibody

Anti-PD-1 Monoclonal Antibody – Cat# MBS3030365

Testing Data of anti-PD-1 antibody

Anti-PD-1 Monoclonal Antibody, Testing Data – Cat# MBS3030365

Other Notes

Small volumes of anti-PD-1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PD-1 purchase

MBS3030365 is an antibody targeting PD-1. Also known as Toripalimab Biosimilar - Research Grade. Reactive in Human. Host: Humanized.

Additional Details

NCBI/Uniprot data below describe general gene information for PD-1. It may not necessarily be applicable to this product.

NCBI GI #
145559515
NCBI GeneID
5133
NCBI Accession #
Q15116.3
UniProt Primary Accession #
Q15116
UniProt Secondary Accession #
O00517; Q8IX89
UniProt Related Accession #
Q15116
NCBI Official Full Name
Programmed cell death protein 1
NCBI Official Synonym Full Names
programmed cell death 1
NCBI Official Symbol
PDCD1
NCBI Official Synonym Symbols
PD1; PD-1; CD279; SLEB2; hPD-1; hPD-l; hSLE1
UniProt Protein Name
Programmed cell death protein 1
UniProt Synonym Protein Names
CD_antigen: CD279
UniProt Gene Name
PDCD1
UniProt Synonym Gene Names
PD1; Protein PD-1; hPD-1
NCBI Protein Information
programmed cell death protein 1

NCBI Summary for PD-1

This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases. [provided by RefSeq, Jul 2008]
Show more

UniProt Comments for PD-1

Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen-specific manner. Possible cell death inducer, in association with other factors.

Research Articles on PD-1

1. Report hyperprogression/reduced progression-free survival during anti-PD-1/PD-L1 therapy in patients with recurrent and/or metastatic head and neck squamous cell carcinoma.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-PD-1 antibody

 Reference Product  PubMed Publications
 CD4 antibody  >415 publications with PD-1 and CD4
 CD274 antibody  >332 publications with PD-1 and CD274
 PDCD1LG2 antibody  >98 publications with PD-1 and PDCD1LG2
 PTPN6 antibody  >7 publications with PD-1 and PTPN6
 PTPN11 antibody  >7 publications with PD-1 and PTPN11
 HLA-DR4 antibody  >1 publications with PD-1 and HLA-DR4

Pathways associated with anti-PD-1 antibody

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Costimulation By The CD28 Family Pathway antibodies  Costimulation By The CD28 Family Pathway Diagram
 Immune System Pathway antibodies  Immune System Pathway Diagram
 PD-1 Signaling Pathway antibodies  PD-1 Signaling Pathway Diagram
 T Cell Receptor Signaling Pathway antibodies  T Cell Receptor Signaling Pathway Diagram
 T Cell Receptor Signaling Pathway antibodies  T Cell Receptor Signaling Pathway Diagram

Organs/Tissues associated with anti-PD-1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >937 publications with PD-1 and Blood
 Kidney Antibodies  >36 publications with PD-1 and Kidney
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000