Porcine CASPASE-4 ELISA Kit – Cat# MBS030820

Caspase 4 (CASPASE-4) ELISA Kit for Porcine

Name: Porcine CASPASE-4 ELISA Kit; Caspase 4; MyBioSource
Brand: MyBioSource
SKU: MBS030820
Price: 675 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS030820

MBS030820 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Caspase 4 (CASPASE-4) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or… More details

$675 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Request Current Manual

Product Overview

Online Datasheet in PDF

Product Name

Caspase 4 (CASPASE-4), ELISA Kit

Full Product Name

Porcine Caspase 4 ELISA Kit

Product Gene Name

CASPASE-4 elisa kit

Species Reactivity

Porcine

Assay Type

Sandwich

Preparation and Storage

Store all reagents at 2-8 degree C

Molecular Weight

43,262 Da

Chromosome Location

Chromosome: 11; NC_000011.9 (104813594..104839325, complement). Location: 11q22.2-q22.3

OMIM

602664

3D Structure

ModBase 3D Structure for P49662

Other Notes

Small volumes of CASPASE-4 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CASPASE-4. It may not necessarily be applicable to this product.

NCBI GI #

15451910

NCBI GeneID

837

NCBI Accession #

NP_150649.1

UniProt Primary Accession #

P49662

UniProt Secondary Accession #

A2NHL8; A2NHM0

UniProt Related Accession #

P49662

GenBank Nucleotide #

NM_033306.2

NCBI Official Full Name

caspase-4 isoform gamma

NCBI Official Synonym Full Names

caspase 4, apoptosis-related cysteine peptidase

NCBI Official Symbol

CASP4

NCBI Official Synonym Symbols

TX; ICH-2; Mih1/TX; ICEREL-II; ICE(rel)II

UniProt Protein Name

Caspase-4

UniProt Synonym Protein Names

ICE(rel)-II; Protease ICH-2; Protease TX

Protein Family

Caspase

UniProt Gene Name

CASP4

UniProt Synonym Gene Names

ICH2; CASP-4

UniProt Entry Name

CASP4_HUMAN

NCBI Protein Information

caspase-4; CASP-4; ICE(rel)-II; protease TX; protease ICH-2; apoptotic cysteine protease Mih1/TX; caspase 4, apoptosis-related cysteine protease

NCBI Summary for CASPASE-4

This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain and a large and small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This caspase is able to cleave and activate its own precursor protein, as well as caspase 1 precursor. When overexpressed, this gene induces cell apoptosis. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

UniProt Comments for CASPASE-4

CASP4: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1. Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a small and a large subunit. Widely expressed, with highest levels in spleen and lung. Moderate expression in heart and liver, low expression in skeletal muscle, kidney and testis. Not found in the brain. Belongs to the peptidase C14A family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Apoptosis; EC 3.4.22.64; Protease

Chromosomal Location of Human Ortholog: 11q22.2-q22.3

Cellular Component: endoplasmic reticulum membrane; mitochondrion; cytoplasm

Molecular Function: cysteine-type endopeptidase activity

Biological Process: regulation of apoptosis; apoptosis; regulation of inflammatory response; proteolysis

Research Articles on CASPASE-4

1. Loss of heterozygosity contributes to tumor progression of oral squamous cell carcinoma, and a specific role for PDCD4, CTNNB1, and CASP4 was found.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with CASPASE-4 elisa kit

Reference Product	PubMed Publications
CASP1 elisa kit	>29 publications with CASPASE-4 and CASP1
CASP8 elisa kit	>16 publications with CASPASE-4 and CASP8
IL18 elisa kit	>5 publications with CASPASE-4 and IL18
CASP10 elisa kit	>3 publications with CASPASE-4 and CASP10
PSEN1 elisa kit	>2 publications with CASPASE-4 and PSEN1
TRAF6 elisa kit	>2 publications with CASPASE-4 and TRAF6
SERPINB9 elisa kit	>1 publications with CASPASE-4 and SERPINB9
APAF1 elisa kit	>1 publications with CASPASE-4 and APAF1

Pathways associated with CASPASE-4 elisa kit

Products by Pathway	Pathway Diagram
Apoptosis Pathway antibodies	Apoptosis Pathway Diagram
Caspase Cascade In Apoptosis Pathway antibodies	Caspase Cascade In Apoptosis Pathway Diagram
Immune System Pathway antibodies	Immune System Pathway Diagram
Innate Immune System Pathway antibodies	Innate Immune System Pathway Diagram
NOD1/2 Signaling Pathway antibodies	NOD1/2 Signaling Pathway Diagram
Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor (NLR) Signaling Pathways antibodies	Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor (NLR) Signaling Pathways Diagram

Diseases associated with CASPASE-4 elisa kit

Disease Name	Pubmed Publications
Neoplasms Antibodies	>50 publications with CASPASE-4 and Neoplasms
Inflammation Antibodies	>12 publications with CASPASE-4 and Inflammation
Necrosis Antibodies	>11 publications with CASPASE-4 and Necrosis
Gastrointestinal Diseases Antibodies	>8 publications with CASPASE-4 and Gastrointestinal Diseases
Carcinoma, Squamous Cell Antibodies	>6 publications with CASPASE-4 and Carcinoma, Squamous Cell
Liver Diseases Antibodies	>6 publications with CASPASE-4 and Liver Diseases
Breast Neoplasms Antibodies	>6 publications with CASPASE-4 and Breast Neoplasms
Cardiovascular Diseases Antibodies	>5 publications with CASPASE-4 and Cardiovascular Diseases
Lung Neoplasms Antibodies	>5 publications with CASPASE-4 and Lung Neoplasms
Lung Diseases Antibodies	>5 publications with CASPASE-4 and Lung Diseases

Organs/Tissues associated with CASPASE-4 elisa kit

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>15 publications with CASPASE-4 and Blood
Liver Antibodies	>9 publications with CASPASE-4 and Liver
Lung Antibodies	>9 publications with CASPASE-4 and Lung
Eye Antibodies	>3 publications with CASPASE-4 and Eye
Vascular Antibodies	>3 publications with CASPASE-4 and Vascular
Kidney Antibodies	>3 publications with CASPASE-4 and Kidney
Mouth Antibodies	>3 publications with CASPASE-4 and Mouth
Heart Antibodies	>3 publications with CASPASE-4 and Heart
Prostate Antibodies	>2 publications with CASPASE-4 and Prostate
Intestine Antibodies	>2 publications with CASPASE-4 and Intestine