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OSR1 Antibody – Rabbit

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS003092

MBS003092 is an antibody targeting OSR1. Also known as Rabbit OSR1 (Phospho-Thr185) Antibody. Reactive in Human, mouse. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
OSR1 (Phospho-Thr185), Antibody
Full Product Name
Rabbit OSR1 (Phospho-Thr185) Antibody
Product Gene Name
anti-OSR1 antibody
Host
Rabbit
Species Reactivity
Human, mouse
Form/Format
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Concentration
1 mg/ml (lot specific)
Molecular Weight
58,022 Da
Chromosome Location
Chromosome: 3; NC_000003.11 (38207026..38296979). Location: 3p22.2
OMIM
604046
3D Structure
ModBase 3D Structure for O95747
Applications Tested/Suitable for anti-OSR1 antibody
ELISA (EIA), Immunohistochemistry (IHC), Western Blot (WB)

Other Notes

Small volumes of anti-OSR1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for OSR1. It may not necessarily be applicable to this product.

NCBI GI #
4826878
NCBI GeneID
9943
NCBI Accession #
NP_005100.1
UniProt Primary Accession #
O95747
UniProt Secondary Accession #
Q3LR53; Q7Z501; Q9UPQ1
UniProt Related Accession #
O95747
GenBank Nucleotide #
NM_005109.2
NCBI Official Full Name
serine/threonine-protein kinase OSR1
NCBI Official Synonym Full Names
oxidative stress responsive 1
NCBI Official Symbol
OXSR1
NCBI Official Synonym Symbols
OSR1
UniProt Protein Name
Serine/threonine-protein kinase OSR1
UniProt Synonym Protein Names
Oxidative stress-responsive 1 protein
Protein Family
Protein odd-skipped
UniProt Gene Name
OXSR1
UniProt Synonym Gene Names
KIAA1101; OSR1
UniProt Entry Name
OXSR1_HUMAN
NCBI Protein Information
serine/threonine-protein kinase OSR1; oxidative-stress responsive 1; oxidative stress-responsive 1 protein

NCBI Summary for OSR1

The product of this gene belongs to the Ser/Thr protein kinase family of proteins. It regulates downstream kinases in response to environmental stress, and may play a role in regulating the actin cytoskeleton. [provided by RefSeq, Jul 2008]

UniProt Comments for OSR1

OSR1: oxidative-stress responsive 1 protein is a ubiquitously expressed protein kinase of the STE20 family. Regulates Na-K-Cl cotransporter (NKCC) activity. Regulates downstream kinases in response to environmental stress. May also have a function in regulating the actin cytoskeleton. Binds to and phosphorylates PAK1. Interacts and is phosphorylated by WNK1. Knockdown of either WNK1 or OXSR1 reduces NKCC activity. Interacts with chloride channel proteins SLC12A6 isoform 2, SLC12A1 and SLC12A2 but not with SLC12A4 and SLC12A7, possibly establishing sensor/signaling modules that initiate the cellular response to environmental stress. An important paralog of this gene is STRADB.

Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, STE; EC 2.7.11.1; Kinase, protein; STE group; STE20 family; FRAY subfamily

Chromosomal Location of Human Ortholog: 3p22.2

Cellular Component: cytoplasm

Molecular Function: protein serine/threonine kinase activity; protein binding; magnesium ion binding; ATP binding; receptor signaling protein serine/threonine kinase activity

Biological Process: peptidyl-threonine phosphorylation; response to oxidative stress; protein amino acid phosphorylation
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Research Articles on OSR1

1. SPAK and OSR1, which are often coexpressed in cells, can form functional heterodimers.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-OSR1 antibody

 Reference Product  PubMed Publications
 PAK1 antibody  >1 publications with OSR1 and PAK1

Diseases associated with anti-OSR1 antibody

 Disease Name  Pubmed Publications
 Hypertension Antibodies  >6 publications with OSR1 and Hypertension
 Cardiovascular Diseases Antibodies  >2 publications with OSR1 and Cardiovascular Diseases
 Necrosis Antibodies  >2 publications with OSR1 and Necrosis
 Hyperkalemia Antibodies  >1 publications with OSR1 and Hyperkalemia
 Kidney Diseases Antibodies  >1 publications with OSR1 and Kidney Diseases
 Fibrosis Antibodies  >1 publications with OSR1 and Fibrosis
 Myocardial Infarction Antibodies  >1 publications with OSR1 and Myocardial Infarction
 Neoplasms Antibodies  >1 publications with OSR1 and Neoplasms
 Lung Neoplasms Antibodies  >1 publications with OSR1 and Lung Neoplasms

Organs/Tissues associated with anti-OSR1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >6 publications with OSR1 and Brain
 Blood Antibodies  >3 publications with OSR1 and Blood
 Prostate Antibodies  >2 publications with OSR1 and Prostate
 Nerve Antibodies  >2 publications with OSR1 and Nerve
 Muscle Antibodies  >1 publications with OSR1 and Muscle
 Kidney Antibodies  >1 publications with OSR1 and Kidney
 Intestine Antibodies  >1 publications with OSR1 and Intestine
 Pancreas Antibodies  >1 publications with OSR1 and Pancreas
 Skin Antibodies  >1 publications with OSR1 and Skin
 Lung Antibodies  >1 publications with OSR1 and Lung
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