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SPON2 Antibody – Rabbit

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS003113

MBS003113 is an antibody targeting SPON2. Also known as Rabbit SPON2 Antibody. Reactive in Human, mouse, rat. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
SPON2, Antibody
Full Product Name
Rabbit SPON2 Antibody
Product Gene Name
anti-SPON2 antibody
Host
Rabbit
Species Reactivity
Human, mouse, rat
Form/Format
Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol
Concentration
1 mg/ml (lot specific)
Molecular Weight
35,846 Da
Chromosome Location
Chromosome: 4; NC_000004.11 (1160720..1202750, complement). Location: 4p16.3
OMIM
605918
3D Structure
ModBase 3D Structure for Q9BUD6
Applications Tested/Suitable for anti-SPON2 antibody
ELISA (EIA), Western Blot (WB)

Other Notes

Small volumes of anti-SPON2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SPON2. It may not necessarily be applicable to this product.

NCBI GI #
190341087
NCBI GeneID
10417
NCBI Accession #
NP_001121797.1
UniProt Primary Accession #
Q9BUD6
UniProt Secondary Accession #
Q4W5N4; Q9ULW1
UniProt Related Accession #
Q9BUD6
GenBank Nucleotide #
NM_001128325.2
NCBI Official Full Name
spondin-2
NCBI Official Synonym Full Names
spondin 2, extracellular matrix protein
NCBI Official Symbol
SPON2
NCBI Official Synonym Symbols
DIL1; DIL-1; MINDIN; M-SPONDIN
UniProt Protein Name
Spondin-2
UniProt Synonym Protein Names
Differentially expressed in cancerous and non-cancerous lung cells 1; DIL-1; Mindin
Protein Family
Spondin
UniProt Gene Name
SPON2
UniProt Synonym Gene Names
DIL1; DIL-1
UniProt Entry Name
SPON2_HUMAN
NCBI Protein Information
spondin-2; differentially expressed in cancerous and non-cancerous lung cells 1

UniProt Comments for SPON2

SPON2: Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern- recognition molecule in the ECM for microbial pathogens. Binds bacterial lipopolysaccharide (LPS).

Protein type: Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 4p16.3

Cellular Component: extracellular space; proteinaceous extracellular matrix

Molecular Function: lipopolysaccharide binding; metal ion binding; antigen binding

Biological Process: induction of bacterial agglutination; mast cell mediated immunity; axon guidance; innate immune response; positive regulation of interleukin-6 production; opsonization; cell adhesion; positive regulation of tumor necrosis factor production; defense response to fungus; defense response to virus
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Research Articles on SPON2

1. Using tissue microarray by immunohistostaining, we found SPON2 to be over-expressed in prostate cancer (PCa). SPON2 staining was more intense in Gleason score sum 7-8 and in PCa patients with metastasis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-SPON2 antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >8 publications with SPON2 and Neoplasms
 Carcinoma Antibodies  >3 publications with SPON2 and Carcinoma
 Ovarian Neoplasms Antibodies  >2 publications with SPON2 and Ovarian Neoplasms
 Necrosis Antibodies  >2 publications with SPON2 and Necrosis
 Fibrosis Antibodies  >1 publications with SPON2 and Fibrosis
 Lung Neoplasms Antibodies  >1 publications with SPON2 and Lung Neoplasms
 Drug Toxicity Antibodies  >1 publications with SPON2 and Drug Toxicity
 Liver Neoplasms Antibodies  >1 publications with SPON2 and Liver Neoplasms
 Kidney Diseases Antibodies  >1 publications with SPON2 and Kidney Diseases
 Carcinoma, Hepatocellular Antibodies  >1 publications with SPON2 and Carcinoma, Hepatocellular

Organs/Tissues associated with anti-SPON2 antibody

 Organ/Tissue Name  Pubmed Publications
 Prostate Antibodies  >5 publications with SPON2 and Prostate
 Ovary Antibodies  >1 publications with SPON2 and Ovary
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