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Epithelial Cell Adhesion Molecule (Ep CAM) (EPCAM) Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS313070

MBS313070 is an antibody targeting Epcam. Also known as MAb to Ep CAM (aa 116-242). Host: Mouse. Hybridization of Sp2/0 myeloma cells with spleen cells from BALB/c mice.; Source: Ascites. More details

$1120 / 1 mg +1 FREE 8GB USB
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
Epithelial Cell Adhesion Molecule (Ep CAM) (Epcam), Monoclonal Antibody
Full Product Name
MAb to Ep CAM (aa 116-242)
Product Gene Name
anti-Epcam antibody
Product Synonym Names
MAb to EpCAM (aa 116-242); Monoclonal Antibody to Human Epithelial Cell Adhesion Molecule (EpCAM), amino acids 116-242.
Clonality
Monoclonal
Isotype
IgG2b
Host
Host: Mouse. Hybridization of Sp2/0 myeloma cells with spleen cells from BALB/c mice.; Source: Ascites
Form/Format
Purified, Liquid
Purity/Purification
> 90% pure (SDS-PAGE). Protein A Chromatography
Specificity
Epithelial Cell Adhesion Molecule (Ep CAM) (a.a. 116-242) (Human Epithelial Cell Adhesion Molecule (EpCAM), amino acids 116-242.)
Preparation and Storage
Store at 2-8 degree C.
Molecular Weight
35,207 Da
Chromosome Location
Chromosome: 6; NC_005105.3 (21264116..21280078, complement). Location: 6q12
3D Structure
ModBase 3D Structure for O55159
Preservative
0.1% Sodium Azide
Immunogen
Recombinant fusion of EpCAM (a.a. 116-242) peptide and human thioredoxin.
Affinity Constant
Not Determined
Buffer
PBS, pH 7.4

Product Categories/Family for anti-Epcam antibody

Monoclonal Antibodies for Cancer Research
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for anti-Epcam antibody
ELISA (EIA), Western Blot (WB)

Other Notes

Small volumes of anti-Epcam antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for Epcam. It may not necessarily be applicable to this product.

NCBI GI #
25742698
NCBI GeneID
171577
NCBI Accession #
NP_612550.1
UniProt Primary Accession #
O55159
UniProt Related Accession #
O55159
GenBank Nucleotide #
NM_138541.1
NCBI Official Full Name
epithelial cell adhesion molecule
NCBI Official Synonym Full Names
epithelial cell adhesion molecule
NCBI Official Symbol
Epcam
NCBI Official Synonym Symbols
Egp314; Tacstd1
UniProt Protein Name
Epithelial cell adhesion molecule
UniProt Synonym Protein Names
Epithelial glycoprotein 314; EGP314; Protein D5.7A; Tumor-associated calcium signal transducer 1
Protein Family
Epithelial cell adhesion molecule
UniProt Gene Name
Epcam
UniProt Synonym Gene Names
Tacstd1; Ep-CAM; EGP314
UniProt Entry Name
EPCAM_RAT
NCBI Protein Information
epithelial cell adhesion molecule; ep-CAM; epithelial glycoprotein 314; tumor-associated calcium signal transducer 1

NCBI Summary for Epcam

involved in metastasis formation and tumor progression [RGD, Feb 2006]

UniProt Comments for Epcam

Function: May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E

By similarity.

Subunit structure: Monomer

By similarity. Interacts with phosphorylated CLDN7. Ref.4

Subcellular location: Lateral cell membrane; Single-pass type I membrane protein. Cell junction › tight junction. Note: Co-localizes with CLDN7 at the lateral cell membrane and tight junction. Ref.4

Post-translational modification: Glycosylation at Asn-198 is crucial for protein stability

By similarity.

Sequence similarities: Belongs to the EPCAM family.Contains 1 thyroglobulin type-1 domain.
Show more

Research Articles on Epcam

1. An association between Tacstd1/EpCam and claudin-7 is noted in rat and human tumors and in non-transformed tissues of the gastrointestinal tract.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Diseases associated with anti-Epcam antibody

 Disease Name  Pubmed Publications
 Neoplasms Antibodies  >626 publications with Epcam and Neoplasms
 Carcinoma Antibodies  >380 publications with Epcam and Carcinoma
 Gastrointestinal Diseases Antibodies  >168 publications with Epcam and Gastrointestinal Diseases
 Neoplasm Metastasis Antibodies  >162 publications with Epcam and Neoplasm Metastasis
 Adenocarcinoma Antibodies  >154 publications with Epcam and Adenocarcinoma
 Breast Neoplasms Antibodies  >124 publications with Epcam and Breast Neoplasms
 Liver Neoplasms Antibodies  >81 publications with Epcam and Liver Neoplasms
 Liver Diseases Antibodies  >75 publications with Epcam and Liver Diseases
 Lung Neoplasms Antibodies  >74 publications with Epcam and Lung Neoplasms
 Neoplasms, Experimental Antibodies  >73 publications with Epcam and Neoplasms, Experimental

Organs/Tissues associated with anti-Epcam antibody

 Organ/Tissue Name  Pubmed Publications
 Colon Antibodies  >102 publications with Epcam and Colon
 Lung Antibodies  >99 publications with Epcam and Lung
 Prostate Antibodies  >49 publications with Epcam and Prostate
 Kidney Antibodies  >36 publications with Epcam and Kidney
 Pancreas Antibodies  >29 publications with Epcam and Pancreas
 Thymus Antibodies  >14 publications with Epcam and Thymus
 Spleen Antibodies  >11 publications with Epcam and Spleen
 Testis Antibodies  >6 publications with Epcam and Testis
 Mammary Gland Antibodies  >5 publications with Epcam and Mammary Gland
 Placenta Antibodies  >3 publications with Epcam and Placenta
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