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Transferrin Receptor Soluble (sTfR) Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS313437

MBS313437 is a recombinant protein targeting sTfR. Also known as Transferrin Receptor Soluble (sTfR). Host: HEK-293 Cell Line. More details

$750 / 0.1 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Transferrin Receptor Soluble (sTfR), Recombinant Protein
Full Product Name
Transferrin Receptor Soluble (sTfR)
Product Gene Name
sTfR recombinant protein
Product Synonym Names
Soluble Transferrin Receptor Recombinant; Soluble Transferrin Receptor
Host
HEK-293 Cell Line
Form/Format
Lyophilized
Purity/Purification
>= 95% pure (SDS-PAGE). Immunoaffinity Chromatography
Preparation and Storage
Store at -20 degree C. After reconstitution, aliquot and freeze at -70 degree C to avoid repeated freeze-thaw cycles.
Molecular Weight
73.8 kDa
OMIM
X01060 mRNA
Tag Note
Product does not contain any tags.
Buffer
10 mM Tris-HCl, 0.15 M Sodium Chloride, pH 8.0, 5% D-Mannitol, 0.1% CHAPS.
Reconstitution
Prepare with deionized water to the initial concentration. If further dilution of the product is needed then use the buffer stated below. If diluting to less than 0.1 mg/mL, do not freeze the product.

Product Categories/Family for sTfR recombinant protein

Pur Cancer
ISO Certification
Manufactured in an ISO 13485:2003 and EN ISO 13485:2012 Certified Laboratory.
Applications Tested/Suitable for sTfR recombinant protein
ELISA (EIA), Immunogen (IM)

Other Notes

Small volumes of sTfR recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for sTfR. It may not necessarily be applicable to this product.

NCBI GI #
339516
NCBI GeneID
7037
NCBI Accession #
AAA61153.1
UniProt Secondary Accession #
Q1HE24; Q59G55; Q9UCN0; Q9UCU5; Q9UDF9; Q9UK21; D3DXB0
UniProt Related Accession #
P02786
NCBI Official Full Name
transferrin receptor
NCBI Official Synonym Full Names
transferrin receptor
NCBI Official Symbol
TFRC
NCBI Official Synonym Symbols
T9; TR; TFR; p90; CD71; TFR1; TRFR; IMD46
UniProt Protein Name
Transferrin receptor protein 1
UniProt Synonym Protein Names
T9; p90; CD_antigen: CD71
Protein Family
Prophage side tail fiber protein
UniProt Gene Name
TFRC
UniProt Synonym Gene Names
TR; TfR; TfR1; Trfr; sTfR
NCBI Protein Information
transferrin receptor protein 1

NCBI Summary for sTfR

This gene encodes a cell surface receptor necessary for cellular iron uptake by the process of receptor-mediated endocytosis. This receptor is required for erythropoiesis and neurologic development. Multiple alternatively spliced variants have been identified. [provided by RefSeq, Sep 2015]

UniProt Comments for sTfR

TfR: the transferrin receptor. Regulates the cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied receptors into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system.

Protein type: Cell surface; Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 3q29

Cellular Component: basolateral plasma membrane; cell surface; coated pit; cytoplasmic vesicle; endosome; external side of plasma membrane; extracellular region; extracellular space; integral to plasma membrane; intracellular membrane-bound organelle; perinuclear region of cytoplasm; plasma membrane; recycling endosome

Molecular Function: double-stranded RNA binding; glycoprotein binding; identical protein binding; protein binding; protein homodimerization activity; transferrin receptor activity; transferrin transmembrane transporter activity

Biological Process: positive regulation of B cell proliferation; positive regulation of isotype switching; positive regulation of T cell proliferation; receptor internalization; regulation of cell growth; regulation of cell proliferation; transferrin transport

Disease: Immunodeficiency 46
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Research Articles on sTfR

1. Data show that the concentration of soluble transferrin receptor with high diagnostic value in the detection of iron deficiency-based anemia in patients undergoing dialysis for chronic renal failure at the end-stage.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with sTfR recombinant protein

 Reference Product  PubMed Publications
 HFE recombinant protein  >24 publications with sTfR and HFE
 B2M recombinant protein  >18 publications with sTfR and B2M
 SLC40A1 recombinant protein  >14 publications with sTfR and SLC40A1
 MYC recombinant protein  >14 publications with sTfR and MYC
 FTH1 recombinant protein  >5 publications with sTfR and FTH1
 STEAP3 recombinant protein  >4 publications with sTfR and STEAP3
 UBC recombinant protein  >4 publications with sTfR and UBC
 HIF1A recombinant protein  >3 publications with sTfR and HIF1A
 OPTN recombinant protein  >1 publications with sTfR and OPTN

Pathways associated with sTfR recombinant protein

 Products by Pathway  Pathway Diagram
 Cargo Recognition For Clathrin-mediated Endocytosis Pathway antibodies  Cargo Recognition For Clathrin-mediated Endocytosis Pathway Diagram
 Clathrin Derived Vesicle Budding Pathway antibodies  Clathrin Derived Vesicle Budding Pathway Diagram
 Clathrin-mediated Endocytosis Pathway antibodies  Clathrin-mediated Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 Endocytosis Pathway antibodies  Endocytosis Pathway Diagram
 FOXA2 And FOXA3 Transcription Factor Networks Pathway antibodies  FOXA2 And FOXA3 Transcription Factor Networks Pathway Diagram
 Golgi Associated Vesicle Biogenesis Pathway antibodies  Golgi Associated Vesicle Biogenesis Pathway Diagram
 HIF-1 Signaling Pathway antibodies  HIF-1 Signaling Pathway Diagram
 HIF-1-alpha Transcription Factor Network Pathway antibodies  HIF-1-alpha Transcription Factor Network Pathway Diagram
 Hematopoietic Cell Lineage Pathway antibodies  Hematopoietic Cell Lineage Pathway Diagram

Diseases associated with sTfR recombinant protein

 Disease Name  Pubmed Publications
 Iron Metabolism Disorders Antibodies  >36 publications with sTfR and Iron Metabolism Disorders
 Anemia Antibodies  >26 publications with sTfR and Anemia
 Disease Models, Animal Antibodies  >25 publications with sTfR and Disease Models, Animal
 Inflammation Antibodies  >15 publications with sTfR and Inflammation
 Anemia, Iron-Deficiency Antibodies  >14 publications with sTfR and Anemia, Iron-Deficiency
 Liver Diseases Antibodies  >11 publications with sTfR and Liver Diseases
 Cardiovascular Diseases Antibodies  >10 publications with sTfR and Cardiovascular Diseases
 Lung Neoplasms Antibodies  >10 publications with sTfR and Lung Neoplasms
 Breast Neoplasms Antibodies  >9 publications with sTfR and Breast Neoplasms
 Colorectal Neoplasms Antibodies  >7 publications with sTfR and Colorectal Neoplasms

Organs/Tissues associated with sTfR recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >66 publications with sTfR and Blood
 Brain Antibodies  >34 publications with sTfR and Brain
 Liver Antibodies  >32 publications with sTfR and Liver
 Bone Antibodies  >18 publications with sTfR and Bone
 Intestine Antibodies  >16 publications with sTfR and Intestine
 Lung Antibodies  >15 publications with sTfR and Lung
 Kidney Antibodies  >14 publications with sTfR and Kidney
 Heart Antibodies  >10 publications with sTfR and Heart
 Vascular Antibodies  >9 publications with sTfR and Vascular
 Skin Antibodies  >9 publications with sTfR and Skin
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