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Intercellular Adhesion Molecule 1 (ICAM-1) ELISA Kit for Canine

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS031396

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only! This kit is intended to be used for determination the level of ICAM-1 (hereafter termed "analyte") in undiluted original Canine body fluids, tissue… More details

$675 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Intercellular Adhesion Molecule 1 (ICAM-1), ELISA Kit
Full Product Name
Canine Intercellular Adhesion Molecule 1 ELISA Kit
Product Gene Name
ICAM-1 elisa kit
Species Reactivity
Canine
Assay Type
Sandwich
Samples
Undiluted original Canine body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
Detection Range
6.25 ng/ml - 200 ng/ml.
Sensitivity
1.0ng/ml.
Specificity
No significant cross-reactivity or interference between this analyte and analogues is observed.
Preparation and Storage
Store all reagents at 2-8 degree C
Inter-assay Precision
Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
Intra-assay Precision
Intra-assay CV (%) is less than 15%.
Molecular Weight
57,825 Da
Chromosome Location
Chromosome: 19; NC_000019.9 (10381517..10397291). Location: 19p13.3-p13.2
OMIM
147840
3D Structure
ModBase 3D Structure for P05362

Other Notes

Small volumes of ICAM-1 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ICAM-1 purchase

MBS031396 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the Intercellular Adhesion Molecule 1 (ICAM-1) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ICAM-1. The ELISA analytical biochemical technique of the MBS031396 kit is based on ICAM-1 antibody-ICAM-1 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ICAM-1 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ICAM-1. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for ICAM-1. It may not necessarily be applicable to this product.

NCBI GI #
167466198
NCBI GeneID
3383
NCBI Accession #
NP_000192.2
UniProt Primary Accession #
P05362
UniProt Secondary Accession #
Q5NKV7; Q96B50; B2R6M3
UniProt Related Accession #
P05362
GenBank Nucleotide #
NM_000201.2
NCBI Official Full Name
intercellular adhesion molecule 1
NCBI Official Synonym Full Names
intercellular adhesion molecule 1
NCBI Official Symbol
ICAM1
NCBI Official Synonym Symbols
BB2; CD54; P3.58
UniProt Protein Name
Intercellular adhesion molecule 1
UniProt Synonym Protein Names
Major group rhinovirus receptor
Protein Family
Intercellular adhesion molecule
UniProt Gene Name
ICAM1
UniProt Synonym Gene Names
ICAM-1
UniProt Entry Name
ICAM1_HUMAN
NCBI Protein Information
intercellular adhesion molecule 1; ICAM-1; cell surface glycoprotein P3.58; major group rhinovirus receptor; intercellular adhesion molecule 1 (CD54), human rhinovirus receptor

NCBI Summary for ICAM-1

This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]

UniProt Comments for ICAM-1

ICAM1: a type I membrane protein of the immunoglobulin superfamily. Is a ligand for the leukocyte adhesion LFA-1 protein (Integrin alpha-L/beta-2) and a Rhinovirus receptor. Typically expressed on endothelial cells and cells of the immune system. ICAM1 binds to integrins of type CD11a / CD18, or CD11b / CD18. Its expression is activated by p53 in an NF-kappaB-independent manner. Induced by TNFalpha in a process that involves IKKbeta.

Protein type: Cell adhesion; Immunoglobulin superfamily; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19p13.3-p13.2

Cellular Component: extracellular space; cell surface; focal adhesion; membrane; integral to plasma membrane; plasma membrane; immunological synapse; external side of plasma membrane

Molecular Function: integrin binding; viral receptor activity; protein binding; transmembrane receptor activity; receptor activity

Biological Process: extracellular matrix organization and biogenesis; entry of virus into host cell; positive regulation of nitric oxide biosynthetic process; T cell antigen processing and presentation; response to organic cyclic substance; activation of NF-kappaB transcription factor; positive regulation of cellular extravasation; regulation of cell shape; cellular response to nutrient levels; leukocyte adhesion; sensory perception of sound; ovarian follicle development; T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; membrane to membrane docking; response to sulfur dioxide; cell adhesion; regulation of leukocyte mediated cytotoxicity; acute inflammatory response to antigenic stimulus; response to drug; regulation of cell adhesion; virion attachment, binding of host cell surface receptor; negative regulation of calcium ion transport; regulation of immune response; cytokine and chemokine mediated signaling pathway; response to amphetamine; cell aging; response to amino acid stimulus; heterophilic cell adhesion; positive regulation of peptidyl-tyrosine phosphorylation; response to ethanol; response to copper ion; positive regulation of actin filament polymerization; positive regulation of vasoconstriction; cell adhesion mediated by integrin; adhesion to host; response to ionizing radiation; leukocyte migration

Disease: Malaria, Susceptibility To
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Research Articles on ICAM-1

1. A possible paracrine role of released platelet miR-320b on endothelial cell intercellular adhesion molecule-1 expression was shown.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with ICAM-1 elisa kit

 Reference Product  PubMed Publications
 ITGB2 elisa kit  >860 publications with ICAM-1 and ITGB2
 ITGAL elisa kit  >467 publications with ICAM-1 and ITGAL
 ITGAM elisa kit  >423 publications with ICAM-1 and ITGAM
 CD44 elisa kit  >356 publications with ICAM-1 and CD44
 ITGAX elisa kit  >134 publications with ICAM-1 and ITGAX
 IL6 elisa kit  >115 publications with ICAM-1 and IL6
 SELE elisa kit  >59 publications with ICAM-1 and SELE
 HLA-B elisa kit  >28 publications with ICAM-1 and HLA-B
 DIF elisa kit  >3 publications with ICAM-1 and DIF

Pathways associated with ICAM-1 elisa kit

 Products by Pathway  Pathway Diagram
 Adaptive Immune System Pathway antibodies  Adaptive Immune System Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 African Trypanosomiasis Pathway antibodies  African Trypanosomiasis Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cell Adhesion Molecules (CAMs) Pathway antibodies  Cell Adhesion Molecules (CAMs) Pathway Diagram
 Cytokine Signaling In Immune System Pathway antibodies  Cytokine Signaling In Immune System Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Glucocorticoid Receptor Regulatory Network Pathway antibodies  Glucocorticoid Receptor Regulatory Network Pathway Diagram
 HTLV-I Infection Pathway antibodies  HTLV-I Infection Pathway Diagram

Diseases associated with ICAM-1 elisa kit

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >5074 publications with ICAM-1 and Inflammation
 Necrosis Antibodies  >4440 publications with ICAM-1 and Necrosis
 Cardiovascular Diseases Antibodies  >3300 publications with ICAM-1 and Cardiovascular Diseases
 Atherosclerosis Antibodies  >1309 publications with ICAM-1 and Atherosclerosis
 Reperfusion Injury Antibodies  >810 publications with ICAM-1 and Reperfusion Injury
 Myocardial Ischemia Antibodies  >740 publications with ICAM-1 and Myocardial Ischemia
 Kidney Diseases Antibodies  >717 publications with ICAM-1 and Kidney Diseases
 Liver Diseases Antibodies  >511 publications with ICAM-1 and Liver Diseases
 Asthma Antibodies  >475 publications with ICAM-1 and Asthma
 Hypertension Antibodies  >474 publications with ICAM-1 and Hypertension

Organs/Tissues associated with ICAM-1 elisa kit

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >11071 publications with ICAM-1 and Blood
 Vascular Antibodies  >8225 publications with ICAM-1 and Vascular
 Lung Antibodies  >1634 publications with ICAM-1 and Lung
 Heart Antibodies  >1179 publications with ICAM-1 and Heart
 Skin Antibodies  >1167 publications with ICAM-1 and Skin
 Liver Antibodies  >1108 publications with ICAM-1 and Liver
 Kidney Antibodies  >1098 publications with ICAM-1 and Kidney
 Brain Antibodies  >1085 publications with ICAM-1 and Brain
 Muscle Antibodies  >959 publications with ICAM-1 and Muscle
 Embryonic Tissue Antibodies  >755 publications with ICAM-1 and Embryonic Tissue
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